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Why is epigenetics important in understanding the pathogenesis of inflammatory musculoskeletal diseases?

Overview of attention for article published in Arthritis Research & Therapy, January 2013
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (64th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

wikipedia
1 Wikipedia page

Citations

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19 Dimensions

Readers on

mendeley
42 Mendeley
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Title
Why is epigenetics important in understanding the pathogenesis of inflammatory musculoskeletal diseases?
Published in
Arthritis Research & Therapy, January 2013
DOI 10.1186/ar4186
Pubmed ID
Authors

Udo Oppermann

Abstract

In its widest sense, the term epigenetics describes a range of mechanisms in genome function that do not solely result from the DNA sequence itself. These mechanisms comprise DNA and chromatin modifications and their associated systems, as well as the noncoding RNA machinery. The epigenetic apparatus is essential for controlling normal development and homeostasis, and also provides a means for the organism to integrate and react upon environmental cues. A multitude of functional studies as well as systematic genome-wide mapping of epigenetic marks and chromatin modifiers reveal the importance of epigenomic mechanisms in human pathologies, including inflammatory conditions and musculoskeletal disease such as rheumatoid arthritis. Collectively, these studies pave the way to identify possible novel therapeutic intervention points and to investigate the utility of drugs that interfere with epigenetic signalling not only in cancer, but possibly also in inflammatory and autoimmune diseases.

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 5%
Brazil 1 2%
Unknown 39 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 24%
Student > Bachelor 7 17%
Researcher 6 14%
Student > Postgraduate 3 7%
Student > Master 3 7%
Other 5 12%
Unknown 8 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 26%
Medicine and Dentistry 10 24%
Chemistry 5 12%
Biochemistry, Genetics and Molecular Biology 3 7%
Pharmacology, Toxicology and Pharmaceutical Science 2 5%
Other 3 7%
Unknown 8 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 November 2014.
All research outputs
#4,970,060
of 15,774,161 outputs
Outputs from Arthritis Research & Therapy
#1,155
of 2,436 outputs
Outputs of similar age
#86,723
of 288,981 outputs
Outputs of similar age from Arthritis Research & Therapy
#13
of 26 outputs
Altmetric has tracked 15,774,161 research outputs across all sources so far. This one is in the 48th percentile – i.e., 48% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,436 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 288,981 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.