Title |
Switching from serotonin reuptake inhibitors to agomelatine in patients with refractory obsessive-compulsive disorder: a 3 month follow-up case series
|
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Published in |
Annals of General Psychiatry, February 2011
|
DOI | 10.1186/1744-859x-10-5 |
Pubmed ID | |
Authors |
Michele Fornaro |
Abstract |
Serotonin reuptake inhibitors (SRIs) currently represent the cornerstone of obsessive-compulsive disorder (OCD) pharmacotherapy. However, OCD is characterized by high rates of partial and/or absent response to standard, recommended treatments, often prompting pharmacological and non-pharmacological augmentation or switching of strategies. Agomelatine, a novel melatonin agonist and selective serotonin antagonist (MASSA) antidepressant approved for major depressive disorder (MDD) has recently been additionally proposed as a treatment for anxiety disorders such as social anxiety disorder (SAD) and panic disorder (PD), but not yet OCD. Nonetheless, agomelatine may have a role in the management of OCD, essentially due to its anxiolytic 5-hydroxytryptamine (HT)2C blockade action, while melatonin (MT)1 and MT2 modulation might contribute to circadian rhythm restoration if impaired. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 65 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 10 | 15% |
Student > Ph. D. Student | 9 | 13% |
Researcher | 8 | 12% |
Student > Master | 8 | 12% |
Student > Doctoral Student | 5 | 7% |
Other | 14 | 21% |
Unknown | 13 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 17 | 25% |
Medicine and Dentistry | 15 | 22% |
Neuroscience | 5 | 7% |
Agricultural and Biological Sciences | 3 | 4% |
Nursing and Health Professions | 3 | 4% |
Other | 7 | 10% |
Unknown | 17 | 25% |