↓ Skip to main content

An unappreciated role for RNA surveillance

Overview of attention for article published in Genome Biology, February 2004
Altmetric Badge

Mentioned by

wikipedia
148 Wikipedia pages

Citations

dimensions_citation
165 Dimensions

Readers on

mendeley
116 Mendeley
citeulike
3 CiteULike
connotea
2 Connotea
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
An unappreciated role for RNA surveillance
Published in
Genome Biology, February 2004
DOI 10.1186/gb-2004-5-2-r8
Pubmed ID
Authors

R Tyler Hillman, Richard E Green, Steven E Brenner

Abstract

Nonsense-mediated mRNA decay (NMD) is a eukaryotic mRNA surveillance mechanism that detects and degrades mRNAs with premature termination codons (PTC+ mRNAs). In mammals, a termination codon is recognized as premature if it lies more than about 50 nucleotides upstream of the final intron position. More than a third of reliably inferred alternative splicing events in humans have been shown to result in PTC+ mRNA isoforms. As the mechanistic details of NMD have only recently been elucidated, we hypothesized that many PTC+ isoforms may have been cloned, characterized and deposited in the public databases, even though they would be targeted for degradation in vivo.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 116 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 3%
United Kingdom 1 <1%
Portugal 1 <1%
Germany 1 <1%
Unknown 109 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 40 34%
Student > Ph. D. Student 25 22%
Professor > Associate Professor 9 8%
Student > Master 9 8%
Student > Bachelor 7 6%
Other 12 10%
Unknown 14 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 56 48%
Biochemistry, Genetics and Molecular Biology 23 20%
Medicine and Dentistry 9 8%
Computer Science 6 5%
Neuroscience 2 2%
Other 4 3%
Unknown 16 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 July 2021.
All research outputs
#8,534,976
of 25,374,647 outputs
Outputs from Genome Biology
#3,489
of 4,467 outputs
Outputs of similar age
#37,569
of 146,590 outputs
Outputs of similar age from Genome Biology
#8
of 18 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 146,590 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.