Title |
An unappreciated role for RNA surveillance
|
---|---|
Published in |
Genome Biology, February 2004
|
DOI | 10.1186/gb-2004-5-2-r8 |
Pubmed ID | |
Authors |
R Tyler Hillman, Richard E Green, Steven E Brenner |
Abstract |
Nonsense-mediated mRNA decay (NMD) is a eukaryotic mRNA surveillance mechanism that detects and degrades mRNAs with premature termination codons (PTC+ mRNAs). In mammals, a termination codon is recognized as premature if it lies more than about 50 nucleotides upstream of the final intron position. More than a third of reliably inferred alternative splicing events in humans have been shown to result in PTC+ mRNA isoforms. As the mechanistic details of NMD have only recently been elucidated, we hypothesized that many PTC+ isoforms may have been cloned, characterized and deposited in the public databases, even though they would be targeted for degradation in vivo. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 3% |
United Kingdom | 1 | <1% |
Portugal | 1 | <1% |
Germany | 1 | <1% |
Unknown | 109 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 40 | 34% |
Student > Ph. D. Student | 25 | 22% |
Professor > Associate Professor | 9 | 8% |
Student > Master | 9 | 8% |
Student > Bachelor | 7 | 6% |
Other | 12 | 10% |
Unknown | 14 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 56 | 48% |
Biochemistry, Genetics and Molecular Biology | 23 | 20% |
Medicine and Dentistry | 9 | 8% |
Computer Science | 6 | 5% |
Neuroscience | 2 | 2% |
Other | 4 | 3% |
Unknown | 16 | 14% |