Title |
The receptor for Granulocyte-colony stimulating factor (G-CSF) is expressed in radial glia during development of the nervous system
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Published in |
BMC Developmental Biology, March 2008
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DOI | 10.1186/1471-213x-8-32 |
Pubmed ID | |
Authors |
Friederike Kirsch, Carola Krüger, Armin Schneider |
Abstract |
Granulocyte colony-stimulating (G-CSF) factor is a well-known hematopoietic growth factor stimulating the proliferation and differentiation of myeloid progenitors. Recently, we uncovered that G-CSF acts also as a neuronal growth factor in the brain, which promotes adult neural precursor differentiation and enhances regeneration of the brain after insults. In adults, the receptor for G-CSF is predominantly expressed in neurons in many brain areas. We also described expression in neurogenic regions of the adult brain, such as the subventricular zone and the subgranular layer of the dentate gyrus. In addition, we found close co-localization of the G-CSF receptor and its ligand G-CSF. Here we have conducted a systematic expression analysis of G-CSF receptor and its ligand in the developing embryo. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 3% |
Brazil | 1 | 3% |
Unknown | 27 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 6 | 21% |
Researcher | 6 | 21% |
Student > Master | 5 | 17% |
Student > Ph. D. Student | 4 | 14% |
Student > Doctoral Student | 2 | 7% |
Other | 3 | 10% |
Unknown | 3 | 10% |
Readers by discipline | Count | As % |
---|---|---|
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Biochemistry, Genetics and Molecular Biology | 5 | 17% |
Neuroscience | 4 | 14% |
Medicine and Dentistry | 3 | 10% |
Nursing and Health Professions | 1 | 3% |
Other | 2 | 7% |
Unknown | 5 | 17% |