Title |
Elevated nerve growth factor and neurotrophin-3 levels in cerebrospinal fluid of children with hydrocephalus
|
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Published in |
BMC Pediatrics, August 2001
|
DOI | 10.1186/1471-2431-1-2 |
Pubmed ID | |
Authors |
Frederike Hochhaus, Petra Koehne, Christoph Schäper, Otfrid Butenandt, Ursula Felderhoff-Mueser, Elfride Ring-Mrozik, Michael Obladen, Christoph Bührer |
Abstract |
Elevated intracranial pressure (ICP) resulting from impaired drainage of cerebrospinal fluid (CSF) causes hydrocephalus with damage to the central nervous system. Clinical symptoms of elevated intracranial pressure (ICP) in infants may be difficult to diagnose, leading to delayed treatment by shunt placement. Until now, no biochemical marker of elevated ICP has been available for clinical diagnosis and monitoring. In experimental animal models, nerve growth factor (NGF) and neurotrophin-3 (NT-3) have been shown to be produced by glial cells as an adaptive response to hypoxia. We investigated whether concentrations of NGF and NT-3 are increased in the CSF of children with hydrocephalus. |
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