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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Transcriptional profiles of different states of cancer stem cells in triple-negative breast cancer
|
|---|---|
| Published in |
Molecular Cancer, February 2018
|
| DOI | 10.1186/s12943-018-0809-x |
| Pubmed ID | |
| Authors |
Mingshan Liu, Yang Liu, Lu Deng, Dong Wang, Xueyan He, Lei Zhou, Max S. Wicha, Fan Bai, Suling Liu |
| Abstract |
Breast cancer stem cells (BCSCs) are thought to be responsible for tumor initiation, metastasis and relapse. Our group and others have described markers useful in isolating BCSCs just as aldehyde dehydrogenase positive (ALDH+) or CD24-CD44+. In fact, cells which simultaneously express both sets of markers have the highest tumor initiating capacity. Although the transcriptomic profile of cells expressing each BCSC marker alone has been reported, the profile of the most tumorigenic population expressing both sets of markers has not. Here we used the biomarker combination of ALDH and CD24/CD44 to sort four populations isolated from triple-negative breast cancer (TNBC) patient-derived xenografts, and performed whole-transcriptome sequencing on each population. We systematically compared the profiles of the three states of BCSCs (ALDH+CD24-CD44+, ALDH+non-CD24-CD44+and ALDH-CD24-CD44+) to that of the differentiated tumor cells (ALDH-non-CD24-CD44+). For the first time, we compared the ALDH+CD24-CD44+BCSCs with the other two BCSC populations. In ALDH+CD24-CD44+BCSCs, we identified P4HA2, PTGR1 and RAB40B as potential prognostic markers, which were virtually related to the status of BCSCs and tumor growth in TNBC cells. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 65 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 31% |
| Student > Master | 10 | 15% |
| Researcher | 5 | 8% |
| Student > Bachelor | 4 | 6% |
| Student > Postgraduate | 3 | 5% |
| Other | 7 | 11% |
| Unknown | 16 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 24 | 37% |
| Medicine and Dentistry | 6 | 9% |
| Agricultural and Biological Sciences | 5 | 8% |
| Engineering | 4 | 6% |
| Physics and Astronomy | 3 | 5% |
| Other | 5 | 8% |
| Unknown | 18 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 March 2018.
All research outputs
#17,932,482
of 23,025,074 outputs
Outputs from Molecular Cancer
#1,210
of 1,732 outputs
Outputs of similar age
#240,165
of 330,329 outputs
Outputs of similar age from Molecular Cancer
#38
of 57 outputs
Altmetric has tracked 23,025,074 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,732 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 330,329 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 57 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.