Title |
Fast-evolving noncoding sequences in the human genome
|
---|---|
Published in |
Genome Biology, June 2007
|
DOI | 10.1186/gb-2007-8-6-r118 |
Pubmed ID | |
Authors |
Christine P Bird, Barbara E Stranger, Maureen Liu, Daryl J Thomas, Catherine E Ingle, Claude Beazley, Webb Miller, Matthew E Hurles, Emmanouil T Dermitzakis |
Abstract |
Gene regulation is considered one of the driving forces of evolution. Although protein-coding DNA sequences and RNA genes have been subject to recent evolutionary events in the human lineage, it has been hypothesized that the large phenotypic divergence between humans and chimpanzees has been driven mainly by changes in gene regulation rather than altered protein-coding gene sequences. Comparative analysis of vertebrate genomes has revealed an abundance of evolutionarily conserved but noncoding sequences. These conserved noncoding (CNC) sequences may well harbor critical regulatory variants that have driven recent human evolution. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 3% |
United Kingdom | 3 | 2% |
Germany | 2 | 1% |
Norway | 1 | <1% |
Korea, Republic of | 1 | <1% |
Israel | 1 | <1% |
France | 1 | <1% |
South Africa | 1 | <1% |
India | 1 | <1% |
Other | 0 | 0% |
Unknown | 178 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 53 | 27% |
Student > Ph. D. Student | 48 | 25% |
Student > Master | 20 | 10% |
Student > Bachelor | 17 | 9% |
Professor > Associate Professor | 8 | 4% |
Other | 29 | 15% |
Unknown | 19 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 89 | 46% |
Biochemistry, Genetics and Molecular Biology | 50 | 26% |
Neuroscience | 12 | 6% |
Medicine and Dentistry | 5 | 3% |
Mathematics | 3 | 2% |
Other | 10 | 5% |
Unknown | 25 | 13% |