Title |
Molecular strategies to inhibit HIV-1 replication
|
---|---|
Published in |
Retrovirology, February 2005
|
DOI | 10.1186/1742-4690-2-10 |
Pubmed ID | |
Authors |
Morten Hjuler Nielsen, Finn Skou Pedersen, Jørgen Kjems |
Abstract |
The human immunodeficiency virus type 1 (HIV-1) is the primary cause of the acquired immunodeficiency syndrome (AIDS), which is a slow, progressive and degenerative disease of the human immune system. The pathogenesis of HIV-1 is complex and characterized by the interplay of both viral and host factors. An intense global research effort into understanding the individual steps of the viral replication cycle and the dynamics during an infection has inspired researchers in the development of a wide spectrum of antiviral strategies. Practically every stage in the viral life cycle and every viral gene product is a potential target. In addition, several strategies are targeting host proteins that play an essential role in the viral life cycle. This review summarizes the main genetic approaches taken in such antiviral strategies. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
South Africa | 3 | 3% |
United States | 2 | 2% |
Brazil | 1 | <1% |
India | 1 | <1% |
Italy | 1 | <1% |
China | 1 | <1% |
Denmark | 1 | <1% |
Venezuela, Bolivarian Republic of | 1 | <1% |
Puerto Rico | 1 | <1% |
Other | 0 | 0% |
Unknown | 102 | 89% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 21 | 18% |
Student > Master | 20 | 18% |
Researcher | 17 | 15% |
Student > Bachelor | 13 | 11% |
Student > Postgraduate | 7 | 6% |
Other | 17 | 15% |
Unknown | 19 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 48 | 42% |
Biochemistry, Genetics and Molecular Biology | 13 | 11% |
Immunology and Microbiology | 8 | 7% |
Medicine and Dentistry | 8 | 7% |
Chemistry | 5 | 4% |
Other | 14 | 12% |
Unknown | 18 | 16% |