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Primaquine-induced haemolysis in females heterozygous for G6PD deficiency

Overview of attention for article published in Malaria Journal, March 2018
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)

Mentioned by

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37 tweeters
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1 Facebook page

Citations

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59 Dimensions

Readers on

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111 Mendeley
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Title
Primaquine-induced haemolysis in females heterozygous for G6PD deficiency
Published in
Malaria Journal, March 2018
DOI 10.1186/s12936-018-2248-y
Pubmed ID
Authors

Cindy S. Chu, Germana Bancone, François Nosten, Nicholas J. White, Lucio Luzzatto

Abstract

Oxidative agents can cause acute haemolytic anaemia in persons with G6PD deficiency. Understanding the relationship between G6PD genotype and the phenotypic expression of the enzyme deficiency is necessary so that severe haemolysis can be avoided. The patterns of oxidative haemolysis have been well described in G6PD deficient hemizygous males and homozygous females; and haemolysis in the proportionally more numerous heterozygous females has been documented mainly following consumption of fava beans and more recently dapsone. It has long been known that 8-aminoquinolines, notably primaquine and tafenoquine, cause acute haemolysis in G6PD deficiency. To support wider use of primaquine in Plasmodium vivax elimination, more data are needed on the haemolytic consequences of 8-aminoquinolines in G6PD heterozygous females. Two recent studies (in 2017) have provided precisely such data; and the need has emerged for the development of point of care quantitative testing of G6PD activity. Another priority is exploring alternative 8-aminoquinoline dosing regimens that are practical and improve safety in G6PD deficient individuals.

Twitter Demographics

The data shown below were collected from the profiles of 37 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 111 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 111 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 14%
Student > Master 15 14%
Researcher 12 11%
Student > Bachelor 12 11%
Student > Postgraduate 7 6%
Other 15 14%
Unknown 34 31%
Readers by discipline Count As %
Medicine and Dentistry 24 22%
Biochemistry, Genetics and Molecular Biology 23 21%
Nursing and Health Professions 5 5%
Agricultural and Biological Sciences 5 5%
Immunology and Microbiology 4 4%
Other 10 9%
Unknown 40 36%

Attention Score in Context

This research output has an Altmetric Attention Score of 31. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 February 2022.
All research outputs
#1,005,519
of 21,712,946 outputs
Outputs from Malaria Journal
#157
of 5,379 outputs
Outputs of similar age
#24,097
of 295,554 outputs
Outputs of similar age from Malaria Journal
#1
of 1 outputs
Altmetric has tracked 21,712,946 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,379 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 295,554 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them