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Evolutionary divergence and functions of the human acyl-CoA thioesterase gene (ACOT) family

Overview of attention for article published in Human Genomics, January 2010
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  • Above-average Attention Score compared to outputs of the same age (62nd percentile)

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Evolutionary divergence and functions of the human acyl-CoA thioesterase gene (ACOT) family
Published in
Human Genomics, January 2010
DOI 10.1186/1479-7364-4-6-411
Pubmed ID

Chad Brocker, Christopher Carpenter, Daniel W Nebert, Vasilis Vasiliou


The acyl-CoA thioesterase gene (ACOT ) family encodes enzymes that catalyse the hydrolysis of acyl-CoA thioester compounds, also known as activated fatty acids, to their corresponding non-esterified (free) fatty acid and coenzyme A (CoASH). These enzymes play a very important role in lipid metabolism by maintaining cellular levels and proper ratios of free and activated fatty acids, as well as CoASH. Within the acyl-CoA family there are two distinct subgroups, type I and type II. Despite catalysing the same reaction, the two groups are not structurally similar and do not share sequence homology, strongly suggesting convergent evolution. This suggestion is further supported if one compares the human with the mouse and rat ACOT gene families. To date, four human type I ACOTs have been identified which belong to the α/β-hydrolase fold enzyme superfamily. Type II ACOTs fall into the 'hot dog' fold superfamily. There are currently six human type II genes; however, two homologous proteins, thioesterase superfamily members 4 (THEM4) and 5 (THEM5) share common type II structural features and, in the case of THEM4, acyl-CoA thioesterase activity--suggesting that the family may be larger than previously realised. Although recent studies have greatly expanded the current understanding of these proteins and their physiological importance, there are a number of members whose functions are relatively unexplored and which warrant further investigation.

Mendeley readers

The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
United States 1 1%
Unknown 73 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 12 16%
Student > Bachelor 11 15%
Researcher 10 13%
Student > Ph. D. Student 10 13%
Student > Doctoral Student 7 9%
Other 13 17%
Unknown 12 16%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 19 25%
Agricultural and Biological Sciences 17 23%
Medicine and Dentistry 7 9%
Pharmacology, Toxicology and Pharmaceutical Science 3 4%
Chemistry 3 4%
Other 10 13%
Unknown 16 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 September 2017.
All research outputs
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Outputs from Human Genomics
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Outputs of similar age
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Outputs of similar age from Human Genomics
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Altmetric has tracked 17,353,889 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 344 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 295,056 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.