Title |
Temporary loss of moral behavior in a patient undergoing chemotherapy with cisplatin - breaking bad
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Published in |
BMC Psychiatry, February 2015
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DOI | 10.1186/s12888-015-0386-0 |
Pubmed ID | |
Authors |
Kristian Barlinn, Hans Lehrach, Timo Siepmann, David Braeuer, Ulrich Buntrock, Norbert Sassim |
Abstract |
BackgroundBehavioral disturbances following chemotherapy with cisplatin are rare. Here, we report a patient with temporary loss of moral behavior in the setting of cisplatin-based chemotherapy for treatment of tonsillar cancer.Case presentationA 66-year-old Caucasian male with no psychiatric or violent history was started on chemotherapy with cisplatin for treatment of tonsillar cancer. During the following weeks, the patient developed profound personality changes involving volatile emotions and impulsive aggression with verbal and physical assaults on others. Admitted to the hospital, the patient lacked any awareness that his behavior was wrong. Chemotherapy was discontinued and the patient was prescribed risperidone. Aside from mild cognitive impairment, comprehensive neuropsychological, neuroradiological and lab testing were unremarkable. Three weeks following cessation of chemotherapy, the patient had recovered to his original mental state and he was completely aware of his wrongdoing and social misconduct.ConclusionSince neurotoxic effects of chemotherapeutics on the brain are not yet sufficiently elucidated, our case emphasizes that early signs of behavioral abnormalities in patients receiving chemotherapy should trigger comprehensive psychiatric evaluation and ongoing monitoring of the patients¿ mental state. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 6 | 17% |
United States | 4 | 11% |
Sweden | 2 | 6% |
Australia | 2 | 6% |
Congo, The Democratic Republic of the | 1 | 3% |
Finland | 1 | 3% |
Denmark | 1 | 3% |
Kyrgyzstan | 1 | 3% |
Unknown | 17 | 49% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 26 | 74% |
Practitioners (doctors, other healthcare professionals) | 5 | 14% |
Scientists | 4 | 11% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Italy | 1 | 2% |
Unknown | 58 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Professor > Associate Professor | 8 | 14% |
Student > Master | 8 | 14% |
Student > Ph. D. Student | 7 | 12% |
Student > Bachelor | 7 | 12% |
Researcher | 5 | 8% |
Other | 12 | 20% |
Unknown | 12 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 12 | 20% |
Nursing and Health Professions | 9 | 15% |
Medicine and Dentistry | 7 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 10% |
Agricultural and Biological Sciences | 5 | 8% |
Other | 8 | 14% |
Unknown | 12 | 20% |