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Mendeley readers
Attention Score in Context
| Title |
Arrestins: ubiquitous regulators of cellular signaling pathways
|
|---|---|
| Published in |
Genome Biology, October 2006
|
| DOI | 10.1186/gb-2006-7-9-236 |
| Pubmed ID | |
| Authors |
Eugenia V Gurevich, Vsevolod V Gurevich |
| Abstract |
In vertebrates, the arrestins are a family of four proteins that regulate the signaling and trafficking of hundreds of different G-protein-coupled receptors (GPCRs). Arrestin homologs are also found in insects, protochordates and nematodes. Fungi and protists have related proteins but do not have true arrestins. Structural information is available only for free (unbound) vertebrate arrestins, and shows that the conserved overall fold is elongated and composed of two domains, with the core of each domain consisting of a seven-stranded beta-sandwich. Two main intramolecular interactions keep the two domains in the correct relative orientation, but both of these interactions are destabilized in the process of receptor binding, suggesting that the conformation of bound arrestin is quite different. As well as binding to hundreds of GPCR subtypes, arrestins interact with other classes of membrane receptors and more than 20 surprisingly diverse types of soluble signaling protein. Arrestins thus serve as ubiquitous signaling regulators in the cytoplasm and nucleus. |
Mendeley readers
The data shown below were compiled from readership statistics for 200 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 1% |
| United States | 2 | 1% |
| Spain | 2 | 1% |
| Canada | 1 | <1% |
| Finland | 1 | <1% |
| Denmark | 1 | <1% |
| Unknown | 191 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 45 | 23% |
| Researcher | 27 | 14% |
| Student > Master | 25 | 13% |
| Student > Bachelor | 23 | 12% |
| Professor | 13 | 7% |
| Other | 33 | 17% |
| Unknown | 34 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 71 | 36% |
| Biochemistry, Genetics and Molecular Biology | 43 | 22% |
| Pharmacology, Toxicology and Pharmaceutical Science | 14 | 7% |
| Neuroscience | 12 | 6% |
| Medicine and Dentistry | 8 | 4% |
| Other | 12 | 6% |
| Unknown | 40 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 August 2020.
All research outputs
#8,534,528
of 25,373,627 outputs
Outputs from Genome Biology
#3,489
of 4,467 outputs
Outputs of similar age
#30,516
of 88,288 outputs
Outputs of similar age from Genome Biology
#11
of 21 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 88,288 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.