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Effectiveness of deep versus moderate muscle relaxation during laparoscopic donor nephrectomy in enhancing postoperative recovery: study protocol for a randomized controlled study

Overview of attention for article published in Trials, March 2017
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Title
Effectiveness of deep versus moderate muscle relaxation during laparoscopic donor nephrectomy in enhancing postoperative recovery: study protocol for a randomized controlled study
Published in
Trials, March 2017
DOI 10.1186/s13063-017-1785-y
Pubmed ID
Authors

Moira H. D. Bruintjes, Andries E. Braat, Albert Dahan, Gert-Jan Scheffer, Luuk B. Hilbrands, Frank C. H. d’Ancona, Rogier A. R. T. Donders, Cornelis J. H. M. van Laarhoven, Michiel C. Warlé

Abstract

Postoperative recovery after live donor nephrectomy is largely determined by the consequences of postoperative pain and analgesia consumptions. The use of deep neuromuscular blockade has been shown to reduce postoperative pain scores after laparoscopic surgery. In this study, we will investigate whether deep neuromuscular blockade also improves the early quality of recovery after live donor nephrectomy. The RELAX-study is a phase IV, multicenter, double-blinded, randomized controlled trial, in which 96 patients, scheduled for living donor nephrectomy, will be randomized into two groups: one with deep and one with moderate neuromuscular blockade. Deep neuromuscular blockade is defined as a post-tetanic count of 1-2. Our primary outcome measurement will be the Quality of Recovery-40 questionnaire (overall score) at 24 h after extubation. This study is, to our knowledge, the first randomized study to assess the effectiveness of deep neuromuscular blockade during laparoscopic donor nephrectomy in enhancing postoperative recovery. The study findings may also be applicable for other laparoscopic procedures. clinicaltrials.gov, NCT02838134 . Registered on 29 June 2016.

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The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 52 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 6 12%
Researcher 6 12%
Other 6 12%
Student > Master 4 8%
Student > Ph. D. Student 4 8%
Other 8 15%
Unknown 18 35%
Readers by discipline Count As %
Medicine and Dentistry 22 42%
Nursing and Health Professions 4 8%
Pharmacology, Toxicology and Pharmaceutical Science 3 6%
Unspecified 2 4%
Computer Science 1 2%
Other 2 4%
Unknown 18 35%