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Curcumin prevents strokes in stroke-prone spontaneously hypertensive rats by improving vascular endothelial function

Overview of attention for article published in BMC Cardiovascular Disorders, March 2018
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2 tweeters
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1 Facebook page

Citations

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24 Dimensions

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25 Mendeley
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Title
Curcumin prevents strokes in stroke-prone spontaneously hypertensive rats by improving vascular endothelial function
Published in
BMC Cardiovascular Disorders, March 2018
DOI 10.1186/s12872-018-0768-6
Pubmed ID
Authors

Cong Lan, Xinjian Chen, Yuxun Zhang, Wei Wang, Wei Eric Wang, Yukai Liu, Yue Cai, Hongmei Ren, Shuo Zheng, Lin Zhou, Chunyu Zeng

Abstract

Antioxidants have shown great promise in stroke prevention. Diarylheptanoids (also known as diphenylheptanoids) are a small class of plant secondary metabolites that possess antioxidant activity greater than that of α-tocopherol. Curcumin is the best known member and is mainly extracted from turmeric. This study aimed to explore whether curcumin has a preventive effect on stroke. Stroke-prone spontaneously hypertensive rats (SHRsp) were randomly divided into control group (n = 10) and curcumin group (n = 10), and saline or curcumin (100 mg/kg/day) was administrated daily. Vascular endothelial function was examined by the relaxation of the artery in response to acetylcholine (ACH). The levels of reactive oxygen species (ROS) and nitric oxide (NO) were measured by using dihydroethidium (DHE) and 4, 5-diaminofluorescein (DAF-2 DA), respectively. The expression of uncoupling protein 2 (UCP2) was examined by RT-PCR and immunoblotting. Administration of curcumin significantly delayed the onset of stroke and increased the survival of SHRsp, which was ascribed to decreased ROS and improved endothelial dependent relaxation of carotid arteries. In the presence of UCP2 inhibitor genipin, both curcumin-mediated decrease of ROS and increase of NO production were blocked. Our study suggests that curcumin exerts a stroke preventive effect by attenuating oxidative stress to improve vascular endothelial function, which might be associated with UCP2 signaling.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 12%
Student > Ph. D. Student 3 12%
Student > Doctoral Student 3 12%
Other 2 8%
Researcher 2 8%
Other 3 12%
Unknown 9 36%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 12%
Neuroscience 3 12%
Pharmacology, Toxicology and Pharmaceutical Science 2 8%
Nursing and Health Professions 2 8%
Biochemistry, Genetics and Molecular Biology 2 8%
Other 4 16%
Unknown 9 36%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 February 2020.
All research outputs
#9,943,488
of 17,043,172 outputs
Outputs from BMC Cardiovascular Disorders
#429
of 1,115 outputs
Outputs of similar age
#143,825
of 284,125 outputs
Outputs of similar age from BMC Cardiovascular Disorders
#1
of 1 outputs
Altmetric has tracked 17,043,172 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,115 research outputs from this source. They receive a mean Attention Score of 3.6. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 284,125 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them