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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Strategies to improve the therapeutic effects of mesenchymal stromal cells in respiratory diseases
|
|---|---|
| Published in |
Stem Cell Research & Therapy, February 2018
|
| DOI | 10.1186/s13287-018-0802-8 |
| Pubmed ID | |
| Authors |
Luisa H. A. Silva, Mariana A. Antunes, Claudia C. Dos Santos, Daniel J. Weiss, Fernanda F. Cruz, Patricia R. M. Rocco |
| Abstract |
Due to their anti-inflammatory, antiapoptotic, antimicrobial, and antifibrotic properties, mesenchymal stromal cells (MSCs) have been considered a promising alternative for treatment of respiratory diseases. Nevertheless, even though MSC administration has been demonstrated to be safe in clinical trials, to date, few studies have shown evidence of MSC efficacy in respiratory diseases. The present review describes strategies to enhance the beneficial effects of MSCs, including preconditioning (under hypoxia, oxidative stress, heat shock, serum deprivation, and exposure to inflammatory biological samples) and genetic manipulation. These strategies can variably promote increases in MSC survival rates, by inducing expression of cytoprotective genes, as well as increase MSC potency by improving secretion of reparative factors. Furthermore, these strategies have been demonstrated to enhance the beneficial effects of MSCs in preclinical lung disease models. However, there is still a long way to go before such strategies can be translated from bench to bedside. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 33% |
| Unknown | 4 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 50% |
| Science communicators (journalists, bloggers, editors) | 2 | 33% |
| Scientists | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 124 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 124 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 18 | 15% |
| Student > Ph. D. Student | 16 | 13% |
| Student > Master | 14 | 11% |
| Student > Bachelor | 14 | 11% |
| Student > Postgraduate | 7 | 6% |
| Other | 15 | 12% |
| Unknown | 40 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 22 | 18% |
| Medicine and Dentistry | 18 | 15% |
| Agricultural and Biological Sciences | 15 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 5% |
| Engineering | 3 | 2% |
| Other | 14 | 11% |
| Unknown | 46 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2018.
All research outputs
#7,349,647
of 23,342,232 outputs
Outputs from Stem Cell Research & Therapy
#732
of 2,454 outputs
Outputs of similar age
#127,045
of 331,046 outputs
Outputs of similar age from Stem Cell Research & Therapy
#23
of 67 outputs
Altmetric has tracked 23,342,232 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 2,454 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,046 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 67 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.