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Mendeley readers
Attention Score in Context
| Title |
High-level inducible Smad4-reexpression in the cervical cancer cell line C4-II is associated with a gene expression profile that predicts a preferential role of Smad4 in extracellular matrix composition
|
|---|---|
| Published in |
BMC Cancer, November 2007
|
| DOI | 10.1186/1471-2407-7-209 |
| Pubmed ID | |
| Authors |
Susanne Klein-Scory, Marc Zapatka, Christina Eilert-Micus, Sabine Hoppe, Elisabeth Schwarz, Wolff Schmiegel, Stephan A Hahn, Irmgard Schwarte-Waldhoff |
| Abstract |
Smad4 is a tumour suppressor frequently inactivated in pancreatic and colorectal cancers. We have recently reported loss of Smad4 in every fourth carcinoma of the uterine cervix. Smad4 transmits signals from the TGF-beta superfamily of cytokines and functions as a versatile transcriptional co-modulator. The prevailing view suggests that the tumour suppressor function of Smad4 primarily resides in its capability to mediate TGF-beta growth inhibitory responses. However, accumulating evidence indicates, that the acquisition of TGF-beta resistance and loss of Smad4 may be independent events in the carcinogenic process. Through inducible reexpression of Smad4 in cervical cancer cells we wished to shed more light on this issue and to identify target genes implicated in Smad4 dependent tumor suppression. |
Mendeley readers
The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 6% |
| Unknown | 16 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 3 | 18% |
| Student > Ph. D. Student | 3 | 18% |
| Professor > Associate Professor | 3 | 18% |
| Student > Bachelor | 2 | 12% |
| Student > Postgraduate | 2 | 12% |
| Other | 3 | 18% |
| Unknown | 1 | 6% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 6 | 35% |
| Agricultural and Biological Sciences | 5 | 29% |
| Biochemistry, Genetics and Molecular Biology | 4 | 24% |
| Unknown | 2 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 August 2022.
All research outputs
#7,574,392
of 23,098,660 outputs
Outputs from BMC Cancer
#2,100
of 8,384 outputs
Outputs of similar age
#25,972
of 77,193 outputs
Outputs of similar age from BMC Cancer
#3
of 6 outputs
Altmetric has tracked 23,098,660 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,384 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 77,193 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.