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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Protection of Malian children from clinical malaria is associated with recognition of multiple antigens
|
|---|---|
| Published in |
Malaria Journal, February 2015
|
| DOI | 10.1186/s12936-015-0567-9 |
| Pubmed ID | |
| Authors |
Modibo Daou, Bourèma Kouriba, Nicolas Ouédraogo, Issa Diarra, Charles Arama, Yamoussa Keita, Sibiri Sissoko, Boucary Ouologuem, Seydou Arama, Teun Bousema, Ogobara K Doumbo, Robert W Sauerwein, Anja Scholzen |
| Abstract |
BackgroundNaturally acquired immunity to clinical malaria is thought to be mainly antibody-mediated, but reports on antigen targets are contradictory. Recognition of multiple antigens may be crucial for protection. In this study, the magnitude of antibody responses and their temporal stability was assessed for a panel of malaria antigens in relation to protection against clinical Plasmodium falciparum malaria.MethodsMalian children aged two to 14 years were enrolled in a longitudinal study and followed up by passive and active case detection for seven months. Plasma was collected at enrolment and at the beginning, in the middle and after the end of the transmission season. Antibody titres to the P. falciparum-antigens apical membrane protein (AMA)-1, merozoite surface protein (MSP)-119, MSP-3, glutamine-rich protein (GLURP-R0) and circumsporozoite antigen (CSP) were assessed by enzyme-linked immunosorbent assay (ELISA) for 99 children with plasma available at all time points. Parasite carriage was determined by microscopy and nested PCR.ResultsAntibody titres to all antigens, except MSP-119, and the number of antigens recognized increased with age. After malaria exposure, antibody titres increased in children that had low titres at baseline, but decreased in those with high baseline responses. No significant differences were found between antibody titers for individual antigens between children remaining symptomatic or asymptomatic after exposure, after adjustment for age. Instead, children remaining asymptomatic following parasite exposure had a broader repertoire of antigen recognition.ConclusionsThe present study provides immune-epidemiological evidence from a limited cohort of Malian children that strong recognition of multiple antigens, rather than antibody titres for individual antigens, is associated with protection from clinical malaria. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Spain | 1 | 1% |
| Kenya | 1 | 1% |
| Unknown | 85 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 22% |
| Student > Master | 15 | 17% |
| Researcher | 12 | 14% |
| Student > Postgraduate | 7 | 8% |
| Student > Bachelor | 6 | 7% |
| Other | 11 | 13% |
| Unknown | 18 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 22 | 25% |
| Medicine and Dentistry | 15 | 17% |
| Immunology and Microbiology | 14 | 16% |
| Biochemistry, Genetics and Molecular Biology | 9 | 10% |
| Social Sciences | 3 | 3% |
| Other | 7 | 8% |
| Unknown | 18 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 January 2016.
All research outputs
#18,397,250
of 22,787,797 outputs
Outputs from Malaria Journal
#5,035
of 5,560 outputs
Outputs of similar age
#256,515
of 352,181 outputs
Outputs of similar age from Malaria Journal
#71
of 103 outputs
Altmetric has tracked 22,787,797 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,560 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 4th percentile – i.e., 4% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,181 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 103 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.