Title |
Imatinib-induced fulminant liver failure in chronic myeloid leukemia: role of liver transplant and second-generation tyrosine kinase inhibitors: a case report
|
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Published in |
Journal of Medical Case Reports, March 2018
|
DOI | 10.1186/s13256-018-1588-0 |
Pubmed ID | |
Authors |
Lucas Souto Nacif, Daniel R. Waisberg, Rafael Soares Pinheiro, Fabiana Roberto Lima, Vinicius Rocha-Santos, Wellington Andraus, Luiz Carneiro D’Albuquerque |
Abstract |
There is a worldwide problem of acute liver failure and mortality associated with remaining on the waiting for a liver transplant. In this study, we highlight results published in recent years by leading transplant centers in evaluating imatinib-induced acute liver failure in chronic myeloid leukemia and follow-up in liver transplantation. A 36-year-old brown-skinned woman (mixed Brazilian race) diagnosed 1 year earlier with chronic myeloid leukemia was started after delivery of a baby and continued for 6 months with imatinib mesylate (selective inhibitor of Bcr-Abl tyrosine kinase), which induced liver failure. We conducted a literature review using the PubMed database for articles published through September 2017, and we demonstrate a role of liver transplant in this situation for imatinib-induced liver failure. We report previously published results and a successful liver transplant after acute liver failure due to imatinib-induced in chronic myeloid leukemia treatment. We report a case of a successful liver transplant after acute liver failure resulting from imatinib-induced chronic myeloid leukemia treatment. The literature reveals the importance of prompt acute liver failure diagnosis and treatment with liver transplant in selected cases. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 38 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 9 | 24% |
Student > Postgraduate | 3 | 8% |
Student > Ph. D. Student | 3 | 8% |
Other | 1 | 3% |
Student > Doctoral Student | 1 | 3% |
Other | 3 | 8% |
Unknown | 18 | 47% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 11 | 29% |
Agricultural and Biological Sciences | 3 | 8% |
Nursing and Health Professions | 3 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Biochemistry, Genetics and Molecular Biology | 1 | 3% |
Other | 1 | 3% |
Unknown | 18 | 47% |