Title |
Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human
|
---|---|
Published in |
Retrovirology, March 2007
|
DOI | 10.1186/1742-4690-4-18 |
Pubmed ID | |
Authors |
Nicolas Gillet, Arnaud Florins, Mathieu Boxus, Catherine Burteau, Annamaria Nigro, Fabian Vandermeers, Hervé Balon, Amel-Baya Bouzar, Julien Defoiche, Arsène Burny, Michal Reichert, Richard Kettmann, Luc Willems |
Abstract |
In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was considered to be the first reported case of bovine leukemia. The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the deltaretrovirus genus which also includes the related human T-lymphotropic virus type 1 (HTLV-1). This review summarizes current knowledge of this viral system, which is important as a model for leukemogenesis. Recently, the BLV model has also cast light onto novel prospects for therapies of HTLV induced diseases, for which no satisfactory treatment exists so far. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Colombia | 1 | <1% |
Germany | 1 | <1% |
France | 1 | <1% |
Ukraine | 1 | <1% |
Argentina | 1 | <1% |
Belgium | 1 | <1% |
Japan | 1 | <1% |
Poland | 1 | <1% |
Unknown | 307 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 96 | 30% |
Student > Ph. D. Student | 37 | 12% |
Student > Master | 37 | 12% |
Researcher | 35 | 11% |
Student > Doctoral Student | 18 | 6% |
Other | 46 | 15% |
Unknown | 46 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 106 | 34% |
Veterinary Science and Veterinary Medicine | 55 | 17% |
Biochemistry, Genetics and Molecular Biology | 42 | 13% |
Immunology and Microbiology | 20 | 6% |
Medicine and Dentistry | 16 | 5% |
Other | 20 | 6% |
Unknown | 56 | 18% |