Title |
Transcriptomic analysis of hepatic responses to testosterone deficiency in miniature pigs fed a high-cholesterol diet
|
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Published in |
BMC Genomics, February 2015
|
DOI | 10.1186/s12864-015-1283-0 |
Pubmed ID | |
Authors |
Zhaowei Cai, Xiaoling Jiang, Yongming Pan, Liang Chen, Lifan Zhang, Keyan Zhu, Yueqin Cai, Yun Ling, Fangming Chen, Xiaoping Xu, Minli Chen |
Abstract |
Recent studies have indicated that low serum testosterone levels are associated with increased risk of developing hepatic steatosis; however, the mechanisms mediating this phenomenon have not been fully elucidated. To gain insight into the role of testosterone in modulating hepatic steatosis, we investigated the effects of testosterone on the development of hepatic steatosis in pigs fed a high-fat and high-cholesterol (HFC) diet and profiled hepatic gene expression by RNA-Seq in HFC-fed intact male pigs (IM), castrated male pigs (CM), and castrated male pigs with testosterone replacement (CMT). |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 44 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 18% |
Student > Master | 8 | 18% |
Professor | 4 | 9% |
Researcher | 4 | 9% |
Student > Doctoral Student | 2 | 5% |
Other | 6 | 14% |
Unknown | 12 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 9 | 20% |
Medicine and Dentistry | 6 | 14% |
Biochemistry, Genetics and Molecular Biology | 4 | 9% |
Nursing and Health Professions | 3 | 7% |
Engineering | 2 | 5% |
Other | 5 | 11% |
Unknown | 15 | 34% |