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Investigations on the interplays between Schistosoma mansoni, praziquantel and the gut microbiome

Overview of attention for article published in Parasites & Vectors, March 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)

Mentioned by

blogs
1 blog
twitter
12 tweeters

Citations

dimensions_citation
38 Dimensions

Readers on

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123 Mendeley
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Title
Investigations on the interplays between Schistosoma mansoni, praziquantel and the gut microbiome
Published in
Parasites & Vectors, March 2018
DOI 10.1186/s13071-018-2739-2
Pubmed ID
Authors

Pierre H. H. Schneeberger, Jean T. Coulibaly, Gordana Panic, Claudia Daubenberger, Morgan Gueuning, Jürg E. Frey, Jennifer Keiser

Abstract

Schistosomiasis is a neglected tropical disease burdening millions of people. One drug, praziquantel, is currently used for treatment and control. Clinically relevant drug resistance has not yet been described, but there is considerable heterogeneity in treatment outcomes, ranging from cure to only moderate egg reduction rates. The objectives of this study are to investigate potential worm-induced dysbacteriosis of the gut microbiota and to assess whether a specific microbiome profile could influence praziquantel response. Using V3 and V4 regions of 16S rRNA genes, we screened the gut microbiota of 34 Schistosoma mansoni infected and uninfected children from Côte d'Ivoire. From each infected child one pre-treatment, one 24-hour and one 21-day follow-up sample after administering 60 mg/kg praziquantel or placebo, were collected. Overall taxonomic profiling and diversity indicators were found to be close to a "healthy" gut structure in all children. Slight overall compositional changes were observed between S. mansoni-infected and non-infected children. Praziquantel treatment was not linked to a major shift in the gut taxonomic profiles, thus reinforcing the good safety profile of the drug by ruling out off-targets effects on the gut microbes.16S rRNA gene of the Fusobacteriales order was significantly more abundant in cured individuals, both at baseline and 24 hours post-treatment. A real-time qPCR confirmed the over-abundance of Fusobacterium spp. in cured children. Fusobacterium spp. abundance could also be correlated with treatment induced S. mansoni egg-reduction. Our study suggests that neither a S. mansoni infection nor praziquantel administration triggers a significant effect on the microbial composition and that a higher abundance of Fusobacterium spp., before treatment, is associated with higher efficacy of praziquantel in the treatment of S. mansoni infections. International Standard Randomised Controlled Trial, number ISRCTN15280205 .

Twitter Demographics

The data shown below were collected from the profiles of 12 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 123 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 123 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 20 16%
Student > Bachelor 18 15%
Student > Master 18 15%
Student > Ph. D. Student 16 13%
Student > Doctoral Student 5 4%
Other 14 11%
Unknown 32 26%
Readers by discipline Count As %
Agricultural and Biological Sciences 26 21%
Medicine and Dentistry 16 13%
Biochemistry, Genetics and Molecular Biology 15 12%
Immunology and Microbiology 6 5%
Nursing and Health Professions 4 3%
Other 19 15%
Unknown 37 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 January 2019.
All research outputs
#1,544,298
of 15,839,330 outputs
Outputs from Parasites & Vectors
#320
of 4,246 outputs
Outputs of similar age
#44,890
of 281,146 outputs
Outputs of similar age from Parasites & Vectors
#1
of 2 outputs
Altmetric has tracked 15,839,330 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,246 research outputs from this source. They receive a mean Attention Score of 4.7. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 281,146 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them