Title |
Cytomegalovirus-induced immunopathology and its clinical consequences
|
---|---|
Published in |
Herpesviridae, April 2011
|
DOI | 10.1186/2042-4280-2-6 |
Pubmed ID | |
Authors |
Stefania Varani, Maria Paola Landini |
Abstract |
Human cytomegalovirus (CMV) is a ubiquitous DNA virus that causes severe disease in patients with immature or impaired immune systems. During active infection, CMV modulates host immunity, and CMV-infected patients often develop signs of immune dysfunction, such as immunosuppression and autoimmune phenomena. Furthermore, active viral infection has been observed in several autoimmune diseases, and case reports have linked primary CMV infection and the onset of autoimmune disorders. In addition, CMV infection promotes allograft rejection and graft-versus-host disease in solid organ and bone marrow transplant recipients, respectively, further implicating CMV in the genesis and maintenance of immunopathological phenomena. The mechanisms by which CMV could induce inhibition of host defense, inflammation, and autoimmunity are discussed, as is the treatment of virus-induced immunopathology with antivirals. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 29% |
France | 1 | 14% |
Unknown | 4 | 57% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 86% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 2 | 1% |
Italy | 1 | <1% |
Brazil | 1 | <1% |
United Kingdom | 1 | <1% |
Canada | 1 | <1% |
Belgium | 1 | <1% |
Russia | 1 | <1% |
Japan | 1 | <1% |
United States | 1 | <1% |
Other | 0 | 0% |
Unknown | 164 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 37 | 21% |
Student > Ph. D. Student | 24 | 14% |
Researcher | 22 | 13% |
Student > Bachelor | 18 | 10% |
Student > Postgraduate | 13 | 7% |
Other | 30 | 17% |
Unknown | 30 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 59 | 34% |
Agricultural and Biological Sciences | 35 | 20% |
Immunology and Microbiology | 15 | 9% |
Biochemistry, Genetics and Molecular Biology | 14 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 3% |
Other | 11 | 6% |
Unknown | 34 | 20% |