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Migration pattern of hepatitis A virus genotype IA in North-Central Tunisia

Overview of attention for article published in Virology Journal, February 2015
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  • Good Attention Score compared to outputs of the same age (71st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (58th percentile)

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Title
Migration pattern of hepatitis A virus genotype IA in North-Central Tunisia
Published in
Virology Journal, February 2015
DOI 10.1186/s12985-015-0249-9
Pubmed ID
Authors

Abir Beji-Hamza, Stefania Taffon, Salma Mhalla, Alessandra Lo Presti, Michele Equestre, Paola Chionne, Elisabetta Madonna, Eleonora Cella, Roberto Bruni, Massimo Ciccozzi, Mahjoub Aouni, Anna Rita Ciccaglione

Abstract

Hepatitis A virus (HAV) epidemiology in Tunisia has changed from high to intermediate endemicity in the last decades. However, several outbreaks continue to occur. The last reported sequences from Tunisian HAV strains date back to 2006. In order to provide an updated overview of the strains currently circulating in Tunisia, a large-scale molecular analysis of samples from hepatitis A cases was performed, the first in Tunisia. Biological samples were collected from patients with laboratory confirmed hepatitis A: 145 sera samples in Tunis, Monastir, Sousse and Kairouan from 2008 to 2013 and 45 stool samples in Mahdia in 2009. HAV isolates were characterised by nested RT-PCR (VP1/2A region) and sequencing. The sequences finally obtained from 81 samples showed 78 genotype IA and 3 genotype IB isolates. A Tunisian genotype IA sequence dataset, including both the 78 newly obtained IA sequences and 51 sequences retrieved from GenBank, was used for phylogenetic investigation, including analysis of migration pattern among six towns. Virus gene flow from Sfax and Monastir was directed to all other towns; in contrast, the gene flows from Sousse, Tunis, Mahdia and Kairouan were directed to three, two, one and no towns, respectively. Several different HAV strains co-circulate in Tunisia, but the predominant genotype still continues to be IA (78/81, 96% isolates). A complex gene flow (migration) of HAV genotype IA was observed, with Sfax and Monastir showing gene flows to all other investigated towns. This approach coupled to a wider sampling can prove useful to investigate the factors underlying the spread of HAV in Tunisia and, thus, to implement appropriate preventing measures.

X Demographics

X Demographics

The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 23%
Student > Ph. D. Student 5 16%
Student > Master 3 10%
Student > Bachelor 2 6%
Other 2 6%
Other 1 3%
Unknown 11 35%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 19%
Immunology and Microbiology 4 13%
Medicine and Dentistry 3 10%
Business, Management and Accounting 1 3%
Nursing and Health Professions 1 3%
Other 4 13%
Unknown 12 39%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 February 2015.
All research outputs
#6,949,323
of 22,787,797 outputs
Outputs from Virology Journal
#780
of 3,042 outputs
Outputs of similar age
#97,194
of 353,662 outputs
Outputs of similar age from Virology Journal
#22
of 53 outputs
Altmetric has tracked 22,787,797 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 3,042 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.7. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 353,662 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.