Title |
Effects of HIV infection and ART on phenotype and function of circulating monocytes, natural killer, and innate lymphoid cells
|
---|---|
Published in |
AIDS Research and Therapy, March 2018
|
DOI | 10.1186/s12981-018-0194-y |
Pubmed ID | |
Authors |
Rose Nabatanzi, Stephen Cose, Moses Joloba, Sarah Rowland Jones, Damalie Nakanjako |
Abstract |
HIV infection causes upregulation of markers of inflammation, immune activation and apoptosis of host adaptive, and innate immune cells particularly monocytes, natural killer (NK) and innate lymphoid cells (ILCs). Although antiretroviral therapy (ART) restores CD4 T-cell counts, the persistent aberrant activation of monocytes, NK and ILCs observed likely contributes to the incomplete recovery of T-cell effector functions. A better understanding of the effects of HIV infection and ART on the phenotype and function of circulating monocytes, NK, and ILCs is required to guide development of novel therapeutic interventions to optimize immune recovery. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Saudi Arabia | 1 | 13% |
Unknown | 7 | 88% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 7 | 88% |
Science communicators (journalists, bloggers, editors) | 1 | 13% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 101 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 18 | 18% |
Student > Master | 17 | 17% |
Student > Bachelor | 8 | 8% |
Researcher | 7 | 7% |
Student > Doctoral Student | 6 | 6% |
Other | 17 | 17% |
Unknown | 28 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 28 | 28% |
Medicine and Dentistry | 17 | 17% |
Biochemistry, Genetics and Molecular Biology | 8 | 8% |
Agricultural and Biological Sciences | 7 | 7% |
Nursing and Health Professions | 4 | 4% |
Other | 6 | 6% |
Unknown | 31 | 31% |