Title |
Mesenchymal stem cells: potential application for the treatment of hepatic cirrhosis
|
---|---|
Published in |
Stem Cell Research & Therapy, March 2018
|
DOI | 10.1186/s13287-018-0814-4 |
Pubmed ID | |
Authors |
Yongting Zhang, Yuwen Li, Lili Zhang, Jun Li, Chuanlong Zhu |
Abstract |
Nowadays, orthotopic liver transplantation is considered the most efficient approach to the end stage of chronic hepatic cirrhosis. Because of the limitations of orthotopic liver transplantation, stem cells are an attractive therapeutic option. Mesenchymal stem cells (MSCs) especially show promise as an alternative treatment for hepatic cirrhosis in animal models and during clinical trials. Nevertheless, the homing of transplanted MSCs to the liver occurs in limited numbers. Therefore, we review the strategies for enhancing the homing of MSCs, mainly via the delivery routes, optimizing cell culture conditions, stimulating the target sites, and genetic modification. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Mexico | 1 | 11% |
United States | 1 | 11% |
Portugal | 1 | 11% |
Unknown | 6 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 67% |
Practitioners (doctors, other healthcare professionals) | 1 | 11% |
Scientists | 1 | 11% |
Science communicators (journalists, bloggers, editors) | 1 | 11% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 46 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 6 | 13% |
Student > Bachelor | 6 | 13% |
Student > Doctoral Student | 5 | 11% |
Researcher | 3 | 7% |
Professor | 2 | 4% |
Other | 6 | 13% |
Unknown | 18 | 39% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 9 | 20% |
Medicine and Dentistry | 6 | 13% |
Agricultural and Biological Sciences | 2 | 4% |
Engineering | 2 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Other | 5 | 11% |
Unknown | 21 | 46% |