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Mendeley readers
Title |
Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK
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Published in |
BMC Molecular and Cell Biology, April 2008
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DOI | 10.1186/1471-2199-9-41 |
Pubmed ID | |
Authors |
Sonja Langmesser, Tiziano Tallone, Alain Bordon, Sandro Rusconi, Urs Albrecht |
Abstract |
Circadian oscillation of clock-controlled gene expression is mainly regulated at the transcriptional level. Heterodimers of CLOCK and BMAL1 act as activators of target gene transcription; however, interactions of PER and CRY proteins with the heterodimer abolish its transcriptional activation capacity. PER and CRY are therefore referred to as negative regulators of the circadian clock. To further elucidate the mechanism how positive and negative components of the clock interplay, we characterized the interactions of PER2, CRY1 and CRY2 with BMAL1 and CLOCK using a mammalian two-hybrid system and co-immunoprecipitation assays. |
Mendeley readers
The data shown below were compiled from readership statistics for 200 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 2% |
Germany | 2 | 1% |
India | 1 | <1% |
Netherlands | 1 | <1% |
Spain | 1 | <1% |
Croatia | 1 | <1% |
Unknown | 191 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 38 | 19% |
Student > Bachelor | 32 | 16% |
Researcher | 28 | 14% |
Student > Master | 22 | 11% |
Professor > Associate Professor | 12 | 6% |
Other | 36 | 18% |
Unknown | 32 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 61 | 31% |
Biochemistry, Genetics and Molecular Biology | 45 | 23% |
Medicine and Dentistry | 19 | 10% |
Neuroscience | 11 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 4% |
Other | 20 | 10% |
Unknown | 36 | 18% |