Title |
Randomized, multicentre assessment of the efficacy and safety of ASAQ – a fixed-dose artesunate-amodiaquine combination therapy in the treatment of uncomplicated Plasmodium falciparum malaria
|
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Published in |
Malaria Journal, June 2009
|
DOI | 10.1186/1475-2875-8-125 |
Pubmed ID | |
Authors |
Jean Louis Ndiaye, Milijaona Randrianarivelojosia, Issaka Sagara, Philippe Brasseur, Ibrahima Ndiaye, Babacar Faye, Laurence Randrianasolo, Arsène Ratsimbasoa, Doris Forlemu, Vicky Ama Moor, Aminata Traore, Yahia Dicko, Niawanlou Dara, Valérie Lameyre, Mouctar Diallo, Abdoulaye Djimde, Albert Same-Ekobo, Oumar Gaye |
Abstract |
The use of artemisinin derivative-based combination therapy (ACT) such as artesunate plus amodiaquine is currently recommended for the treatment of uncomplicated Plasmodium falciparum malaria. Fixed-dose combinations are more adapted to patients than regimens involving multiple tablets and improve treatment compliance. A fixed-dose combination of artesunate + amodiaquine (ASAQ) was recently developed. To assess the efficacy and safety of this new combination and to define its optimum dosage regimen (once or twice daily) in the treatment of uncomplicated P. falciparum malaria, a multicentre clinical study was conducted. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 2% |
France | 2 | 1% |
Netherlands | 1 | <1% |
Brazil | 1 | <1% |
Mali | 1 | <1% |
Belgium | 1 | <1% |
United States | 1 | <1% |
Unknown | 152 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 29 | 18% |
Student > Master | 26 | 16% |
Student > Ph. D. Student | 24 | 15% |
Other | 14 | 9% |
Student > Doctoral Student | 13 | 8% |
Other | 29 | 18% |
Unknown | 27 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 55 | 34% |
Agricultural and Biological Sciences | 19 | 12% |
Biochemistry, Genetics and Molecular Biology | 13 | 8% |
Psychology | 9 | 6% |
Social Sciences | 8 | 5% |
Other | 21 | 13% |
Unknown | 37 | 23% |