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Mendeley readers
Attention Score in Context
| Title |
Variation in the gene coding for the M5 Muscarinic receptor (CHRM5) influences cigarette dose but is not associated with dependence to drugs of addiction: evidence from a prospective population based cohort study of young adults
|
|---|---|
| Published in |
BMC Genomic Data, July 2007
|
| DOI | 10.1186/1471-2156-8-46 |
| Pubmed ID | |
| Authors |
Richard JL Anney, Mehrnoush Lotfi-Miri, Craig A Olsson, Sophie C Reid, Sheryl A Hemphill, George C Patton |
| Abstract |
The mesolimbic structures of the brain are important in the anticipation and perception of reward. Moreover, many drugs of addiction elicit their response in these structures. The M5 muscarinic receptor (M5R) is expressed in dopamine-containing neurones of the substantia nigra pars compacta and ventral tegmental area, and regulates the release of mesolimbic dopamine. Mice lacking M5R show a substantial reduction in both reward and withdrawal responses to morphine and cocaine. The CHRM5, the gene that codes for the M5R, is a strong biological candidate for a role in human addiction. We screened the coding and core promoter sequences of CHRM5 using denaturing high performance liquid chromatography to identify common polymorphisms. Additional polymorphisms within the coding and core promoter regions that were identified through dbSNP were validated in the test population. We investigated whether these polymorphisms influence substance dependence and dose in a cohort of 1947 young Australians. |
Mendeley readers
The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 42 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 23% |
| Student > Doctoral Student | 4 | 9% |
| Student > Bachelor | 4 | 9% |
| Student > Master | 4 | 9% |
| Researcher | 4 | 9% |
| Other | 4 | 9% |
| Unknown | 13 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 6 | 14% |
| Agricultural and Biological Sciences | 6 | 14% |
| Medicine and Dentistry | 5 | 12% |
| Social Sciences | 3 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 7% |
| Other | 4 | 9% |
| Unknown | 16 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 March 2012.
All research outputs
#8,534,976
of 25,373,627 outputs
Outputs from BMC Genomic Data
#316
of 1,204 outputs
Outputs of similar age
#28,405
of 78,478 outputs
Outputs of similar age from BMC Genomic Data
#3
of 8 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,204 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 78,478 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.