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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Exercise-induced increase in brain-derived neurotrophic factor in human Parkinson's disease: a systematic review and meta-analysis
|
|---|---|
| Published in |
Translational Neurodegeneration, March 2018
|
| DOI | 10.1186/s40035-018-0112-1 |
| Pubmed ID | |
| Authors |
Mark A. Hirsch, Erwin E. H. van Wegen, Mark A. Newman, Patricia C. Heyn |
| Abstract |
Animal models of exercise and Parkinson's disease (PD) have found that the physiologic use of exercise may interact with the neurodegenerative disease process, likely mediated by brain derived neurotrophic factor (BDNF). No reviews so far have assessed the methodologic quality of available intervention studies or have bundled the effect sizes of individual studies on exercise-induced effects on BDNF blood levels in human PD. We searched MEDLINE, EMBASE, Cochrane Library, PsycINFO and PubMed from inception to June 2017. Data aggregated from two randomized controlled trials and four pre-experimental studies with a total of 100 ambulatory patients with idiopathic PD (Hoehn/Yahr ≤3) found improvements in BDNF blood concentration levels in all 6 studies (two RCTs and 4 pre-experimental studies). Pooled BDNF level change scores from the 2 RCTs resulted in a significant homogeneous summary effect size (Standardized Mean Difference 2.06, 95% CI 1.36 to 2.76), and a significant heterogeneous SES for the motor part of the UPDRS-III examination (MD -5.53, 95% CI -10.42 to -0.64). Clinical improvements were noted in all studies using a variety of outcome measures. The evidence-base consists primarily of small studies with low to moderate methodological quality. This review provides preliminary evidence for the effectiveness of physical exercise treatments for persons with PD on BDNF blood levels. Further research is needed. |
X Demographics
The data shown below were collected from the profiles of 22 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 27% |
| Canada | 2 | 9% |
| United Kingdom | 2 | 9% |
| Indonesia | 1 | 5% |
| Ireland | 1 | 5% |
| Finland | 1 | 5% |
| Netherlands | 1 | 5% |
| Unknown | 8 | 36% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 16 | 73% |
| Practitioners (doctors, other healthcare professionals) | 5 | 23% |
| Scientists | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 189 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 189 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 32 | 17% |
| Student > Master | 23 | 12% |
| Student > Ph. D. Student | 21 | 11% |
| Researcher | 18 | 10% |
| Student > Doctoral Student | 11 | 6% |
| Other | 29 | 15% |
| Unknown | 55 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Nursing and Health Professions | 28 | 15% |
| Neuroscience | 25 | 13% |
| Medicine and Dentistry | 17 | 9% |
| Sports and Recreations | 13 | 7% |
| Psychology | 10 | 5% |
| Other | 29 | 15% |
| Unknown | 67 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 July 2021.
All research outputs
#2,426,853
of 25,382,440 outputs
Outputs from Translational Neurodegeneration
#86
of 384 outputs
Outputs of similar age
#50,619
of 348,083 outputs
Outputs of similar age from Translational Neurodegeneration
#2
of 9 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 384 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 29.7. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 348,083 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.