Title |
Successful treatment with pazopanib plus PD-1 inhibitor and RAK cells for advanced primary hepatic angiosarcoma: a case report
|
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Published in |
BMC Cancer, February 2018
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DOI | 10.1186/s12885-018-3996-3 |
Pubmed ID | |
Authors |
Yu Qiao, Jihong Yang, Lili Liu, Yixin Zeng, Jie Ma, Jing Jia, Li Zhang, Xiaoguang Li, Peihong Wu, Wenchao Wang, Dongge Liu, Huan Chen, Yunbo Zhao, Huan Xi, Yao Wang |
Abstract |
Primary hepatic angiosarcoma (PHA) is a rare and aggressive solid tumor, with high rates of local recurrence and distant metastasis, and poor prognosis. There are no established treatment guidelines for PHA. A 78-year-old asymptomatic man with PHA that was successfully treated with pazopanib plus PD-1 inhibitor and RetroNectin-activated killer cells (RAK cells). After one month of treatment, there was a clear reduction in the size and number of the liver metastases; and after nearly 15 months, most of the lesions were stable, no new lesions had developed, and the side effect of treatment was minor. Pazopanib, PD-1 inhibitor and RAK cells could serve as a potential option for the treatment of advanced PHA. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 3 | 14% |
Professor > Associate Professor | 3 | 14% |
Student > Bachelor | 2 | 10% |
Student > Master | 2 | 10% |
Student > Postgraduate | 2 | 10% |
Other | 2 | 10% |
Unknown | 7 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 43% |
Computer Science | 1 | 5% |
Nursing and Health Professions | 1 | 5% |
Psychology | 1 | 5% |
Engineering | 1 | 5% |
Other | 0 | 0% |
Unknown | 8 | 38% |