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Physical therapy and deep brain stimulation in Parkinson’s Disease: protocol for a pilot randomized controlled trial

Overview of attention for article published in Pilot and Feasibility Studies, February 2018
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Title
Physical therapy and deep brain stimulation in Parkinson’s Disease: protocol for a pilot randomized controlled trial
Published in
Pilot and Feasibility Studies, February 2018
DOI 10.1186/s40814-018-0243-2
Pubmed ID
Authors

Ryan P. Duncan, Linda R. Van Dillen, Jane M. Garbutt, Gammon M. Earhart, Joel S. Perlmutter

Abstract

Subthalamic nucleus deep brain stimulation (STN-DBS) reduces tremor, muscle stiffness, and bradykinesia in people with Parkinson's Disease (PD). Walking speed, known to be reduced in PD, typically improves after surgery; however, other important aspects of gait may not improve. Furthermore, balance may worsen and falls may increase after STN-DBS. Thus, interventions to improve balance and gait could reduce morbidity and improve quality of life following STN-DBS. Physical therapy (PT) effectively improves balance and gait in people with PD, but studies on the effects of PT have not been extended to those treated with STN-DBS. As such, the efficacy, safety, and feasibility of PT in this population remain to be determined. The purpose of this pilot study is to address these unmet needs. We hypothesize that PT designed to target balance and gait impairment will be effective, safe, and feasible in this population. Participants with PD treated with STN-DBS will be randomly assigned to either a PT or control group. Participants assigned to PT will complete an 8-week, twice-weekly PT program consisting of exercises designed to improve balance and gait. Control group participants will receive the current standard of care following STN-DBS, which does not include prescription of PT. The primary aim is to assess preliminary efficacy of PT on balance (Balance Evaluation Systems Test). A secondary aim is to assess efficacy of PT on gait (GAITRite instrumented walkway). Participants will be assessed OFF medication/OFF stimulation and ON medication/ON stimulation at baseline and at 8 and 12 weeks after baseline. Adverse events will be measured over the duration of the study, and adherence to PT will be measured to determine feasibility. To our knowledge, this will be the first study to explore the preliminary efficacy, safety, and feasibility of PT for individuals with PD with STN-DBS. If the study suggests potential efficacy, then this would justify larger trials to test effectiveness and safety of PT for those with PD with STN-DBS. NCT03181282 (clinicaltrials.gov). Registered on 7 June 2017.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 91 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 19 21%
Student > Master 10 11%
Student > Doctoral Student 9 10%
Student > Ph. D. Student 8 9%
Unspecified 6 7%
Other 9 10%
Unknown 30 33%
Readers by discipline Count As %
Nursing and Health Professions 18 20%
Medicine and Dentistry 13 14%
Unspecified 6 7%
Neuroscience 4 4%
Sports and Recreations 4 4%
Other 16 18%
Unknown 30 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 March 2020.
All research outputs
#14,379,536
of 23,028,364 outputs
Outputs from Pilot and Feasibility Studies
#664
of 1,047 outputs
Outputs of similar age
#188,167
of 331,227 outputs
Outputs of similar age from Pilot and Feasibility Studies
#29
of 38 outputs
Altmetric has tracked 23,028,364 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,047 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,227 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.