Title |
Duplication and selection in the evolution of primate β-defensin genes
|
---|---|
Published in |
Genome Biology, April 2003
|
DOI | 10.1186/gb-2003-4-5-r31 |
Pubmed ID | |
Authors |
Colin AM Semple, Mark Rolfe, Julia R Dorin |
Abstract |
Innate immunity is the first line of defense against microorganisms in vertebrates and acts by providing an initial barrier to microorganisms and triggering adaptive immune responses. Peptides such as beta-defensins are an important component of this defense, providing a broad spectrum of antimicrobial activity against bacteria, fungi, mycobacteria and several enveloped viruses. Beta-defensins are small cationic peptides that vary in their expression patterns and spectrum of pathogen specificity. Disruptions in beta-defensin function have been implicated in human diseases, including cystic fibrosis, and a fuller understanding of the variety, function and evolution of human beta-defensins might form the basis for novel therapies. Here we use a combination of laboratory and computational techniques to characterize the main human beta-defensin locus on chromosome 8p22-p23. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 4% |
Australia | 1 | 1% |
Brazil | 1 | 1% |
Netherlands | 1 | 1% |
Belgium | 1 | 1% |
Denmark | 1 | 1% |
Japan | 1 | 1% |
United States | 1 | 1% |
Unknown | 65 | 87% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 18 | 24% |
Researcher | 16 | 21% |
Student > Bachelor | 9 | 12% |
Student > Master | 7 | 9% |
Professor | 5 | 7% |
Other | 11 | 15% |
Unknown | 9 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 33 | 44% |
Biochemistry, Genetics and Molecular Biology | 12 | 16% |
Medicine and Dentistry | 6 | 8% |
Immunology and Microbiology | 5 | 7% |
Chemistry | 5 | 7% |
Other | 4 | 5% |
Unknown | 10 | 13% |