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Duplication and selection in the evolution of primate β-defensin genes

Overview of attention for article published in Genome Biology, April 2003
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11 Wikipedia pages

Citations

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131 Dimensions

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75 Mendeley
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Title
Duplication and selection in the evolution of primate β-defensin genes
Published in
Genome Biology, April 2003
DOI 10.1186/gb-2003-4-5-r31
Pubmed ID
Authors

Colin AM Semple, Mark Rolfe, Julia R Dorin

Abstract

Innate immunity is the first line of defense against microorganisms in vertebrates and acts by providing an initial barrier to microorganisms and triggering adaptive immune responses. Peptides such as beta-defensins are an important component of this defense, providing a broad spectrum of antimicrobial activity against bacteria, fungi, mycobacteria and several enveloped viruses. Beta-defensins are small cationic peptides that vary in their expression patterns and spectrum of pathogen specificity. Disruptions in beta-defensin function have been implicated in human diseases, including cystic fibrosis, and a fuller understanding of the variety, function and evolution of human beta-defensins might form the basis for novel therapies. Here we use a combination of laboratory and computational techniques to characterize the main human beta-defensin locus on chromosome 8p22-p23.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 4%
Australia 1 1%
Brazil 1 1%
Netherlands 1 1%
Belgium 1 1%
Denmark 1 1%
Japan 1 1%
United States 1 1%
Unknown 65 87%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 24%
Researcher 16 21%
Student > Bachelor 9 12%
Student > Master 7 9%
Professor 5 7%
Other 11 15%
Unknown 9 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 33 44%
Biochemistry, Genetics and Molecular Biology 12 16%
Medicine and Dentistry 6 8%
Immunology and Microbiology 5 7%
Chemistry 5 7%
Other 4 5%
Unknown 10 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 September 2017.
All research outputs
#8,534,976
of 25,374,647 outputs
Outputs from Genome Biology
#3,489
of 4,467 outputs
Outputs of similar age
#20,509
of 62,382 outputs
Outputs of similar age from Genome Biology
#9
of 23 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 62,382 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.