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Regulation of Akt(ser473) phosphorylation by Choline kinase in breast carcinoma cells

Overview of attention for article published in Molecular Cancer, December 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (78th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

patent
1 patent
wikipedia
1 Wikipedia page

Citations

dimensions_citation
57 Dimensions

Readers on

mendeley
60 Mendeley
citeulike
1 CiteULike
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Title
Regulation of Akt(ser473) phosphorylation by Choline kinase in breast carcinoma cells
Published in
Molecular Cancer, December 2009
DOI 10.1186/1476-4598-8-131
Pubmed ID
Authors

Boon Tin Chua, David Gallego-Ortega, Ana Ramirez de Molina, Axel Ullrich, Juan Carlos Lacal, Julian Downward

Abstract

The serine/threonine kinase PKB/Akt plays essential role in various cellular processes including cell growth and proliferation, metabolism and cell survival. The importance of the Akt pathway is highlighted by the mutation of various components of the pathway such as the PTEN and PI3-kinase (P110alpha) in human cancers. In this paper, we employed an RNA interference library targeting all human kinases to screen for kinases involved in the regulation of Akt activation, in particular serine 473 phosphorylation. Here, we transfected the MDA-MB 468 breast cell line with the human kinome siRNA library and measured Akt activation using an antibody specific for phosphoserine 473 of Akt.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Spain 1 2%
Italy 1 2%
Unknown 57 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 23%
Researcher 12 20%
Student > Doctoral Student 7 12%
Student > Master 6 10%
Student > Bachelor 4 7%
Other 9 15%
Unknown 8 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 23 38%
Biochemistry, Genetics and Molecular Biology 10 17%
Medicine and Dentistry 7 12%
Pharmacology, Toxicology and Pharmaceutical Science 5 8%
Chemistry 2 3%
Other 3 5%
Unknown 10 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2017.
All research outputs
#5,446,629
of 25,374,647 outputs
Outputs from Molecular Cancer
#443
of 1,919 outputs
Outputs of similar age
#29,260
of 172,523 outputs
Outputs of similar age from Molecular Cancer
#3
of 18 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,919 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 172,523 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.