Title |
The Mre11 protein interacts with both Rad50 and the HerA bipolar helicase and is recruited to DNA following gamma irradiation in the archaeon Sulfolobus acidocaldarius
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Published in |
BMC Molecular and Cell Biology, February 2008
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DOI | 10.1186/1471-2199-9-25 |
Pubmed ID | |
Authors |
Achim Quaiser, Florence Constantinesco, Malcolm F White, Patrick Forterre, Christiane Elie |
Abstract |
The ubiquitous Rad50 and Mre11 proteins play a key role in many processes involved in the maintenance of genome integrity in Bacteria and Eucarya, but their function in the Archaea is presently unknown. We showed previously that in most hyperthermophilic archaea, rad50-mre11 genes are linked to nurA encoding both a single-strand endonuclease and a 5' to 3' exonuclease, and herA, encoding a bipolar DNA helicase which suggests the involvement of the four proteins in common molecular pathway(s). Since genetic tools for hyperthermophilic archaea are just emerging, we utilized immuno-detection approaches to get the first in vivo data on the role(s) of these proteins in the hyperthermophilic crenarchaeon Sulfolobus acidocaldarius. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 2% |
Poland | 1 | 2% |
Germany | 1 | 2% |
Unknown | 52 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 25% |
Researcher | 12 | 22% |
Student > Master | 10 | 18% |
Professor | 6 | 11% |
Student > Bachelor | 3 | 5% |
Other | 5 | 9% |
Unknown | 5 | 9% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 13 | 24% |
Medicine and Dentistry | 2 | 4% |
Environmental Science | 1 | 2% |
Physics and Astronomy | 1 | 2% |
Other | 1 | 2% |
Unknown | 5 | 9% |