Title |
Belimumab and low-doses of mycophenolate mofetil as induction therapy of class IV lupus nephritis: case series and literature review
|
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Published in |
BMC Nephrology, March 2018
|
DOI | 10.1186/s12882-018-0847-z |
Pubmed ID | |
Authors |
Domenico Paolo Emanuele Margiotta, Fabio Basta, Veronica Batani, Antonella Afeltra |
Abstract |
The treatment of Lupus Nephritis (LN) is an unmet need in the management of patients with Systemic Lupus Erythematosus (SLE). CASE PRESENTATION : We report two cases of women affected by Lupus Nephritis (LN) ISN/RNP Class IV with serological active disease, high disease activity and marked fatigue. In both cases, Mycophenolate mofetil (MMF), as induction therapy, was poorly tolerated because of gastrointestinal toxicity. Belimumab, together with low-doses of MMF, was effective as induction treatment leading to early achievement of complete renal response in these two selected cases of LN. We also report a literature review concerning the efficacy and safety of Belimumab in Lupus Nephritis. Further studies are needed to evaluate the use of Belimumab to manage the renal involvement in patients with Systemic Lupus Erythematosus, waiting for the results of ongoing randomized clinical trials. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Japan | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 45 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 5 | 11% |
Researcher | 5 | 11% |
Student > Doctoral Student | 5 | 11% |
Student > Bachelor | 5 | 11% |
Other | 4 | 9% |
Other | 11 | 24% |
Unknown | 10 | 22% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 22 | 49% |
Immunology and Microbiology | 3 | 7% |
Chemistry | 2 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Agricultural and Biological Sciences | 1 | 2% |
Other | 6 | 13% |
Unknown | 10 | 22% |