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Belimumab and low-doses of mycophenolate mofetil as induction therapy of class IV lupus nephritis: case series and literature review

Overview of attention for article published in BMC Nephrology, March 2018
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Title
Belimumab and low-doses of mycophenolate mofetil as induction therapy of class IV lupus nephritis: case series and literature review
Published in
BMC Nephrology, March 2018
DOI 10.1186/s12882-018-0847-z
Pubmed ID
Authors

Domenico Paolo Emanuele Margiotta, Fabio Basta, Veronica Batani, Antonella Afeltra

Abstract

The treatment of Lupus Nephritis (LN) is an unmet need in the management of patients with Systemic Lupus Erythematosus (SLE). CASE PRESENTATION : We report two cases of women affected by Lupus Nephritis (LN) ISN/RNP Class IV with serological active disease, high disease activity and marked fatigue. In both cases, Mycophenolate mofetil (MMF), as induction therapy, was poorly tolerated because of gastrointestinal toxicity. Belimumab, together with low-doses of MMF, was effective as induction treatment leading to early achievement of complete renal response in these two selected cases of LN. We also report a literature review concerning the efficacy and safety of Belimumab in Lupus Nephritis. Further studies are needed to evaluate the use of Belimumab to manage the renal involvement in patients with Systemic Lupus Erythematosus, waiting for the results of ongoing randomized clinical trials.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 45 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 11%
Researcher 5 11%
Student > Doctoral Student 5 11%
Student > Bachelor 5 11%
Other 4 9%
Other 11 24%
Unknown 10 22%
Readers by discipline Count As %
Medicine and Dentistry 22 49%
Immunology and Microbiology 3 7%
Chemistry 2 4%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Agricultural and Biological Sciences 1 2%
Other 6 13%
Unknown 10 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 March 2019.
All research outputs
#17,934,709
of 23,028,364 outputs
Outputs from BMC Nephrology
#1,730
of 2,498 outputs
Outputs of similar age
#241,822
of 332,620 outputs
Outputs of similar age from BMC Nephrology
#25
of 38 outputs
Altmetric has tracked 23,028,364 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,498 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 332,620 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.