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Systemic inflammation in dogs with advanced-stage heart failure

Overview of attention for article published in Acta Veterinaria Scandinavica, March 2018
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Title
Systemic inflammation in dogs with advanced-stage heart failure
Published in
Acta Veterinaria Scandinavica, March 2018
DOI 10.1186/s13028-018-0372-x
Pubmed ID
Authors

Aleksandra Domanjko Petrič, Tajda Lukman, Barbara Verk, Alenka Nemec Svete

Abstract

Although human studies have shown that inflammation plays a role in the development of congestive heart failure, scarce information exists on white blood cell count (WBC) and differential cell counts in various stages of heart failure in man and dogs. A few studies demonstrated increased concentrations of C-reactive protein (CRP), a major acute-phase protein, in cardiac diseases in dogs. Our research aimed to investigate whether CRP concentration, WBC and neutrophil count (NEUT), as markers of systemic inflammation, are elevated in canine cardiovascular patients. We also aimed to find out whether there is an association between CRP concentration and WBC and NEUT, as well as associations between these inflammatory markers and selected echocardiographic parameters. Sixty-two client-owned canine cardiac patients and 12 healthy dogs were included in the study. The patients were classified into International Small Animal Cardiac Health Council classes (ISACHC I-III). The serum CRP concentration was determined using a canine CRP test kit. WBC and NEUT were determined using an automated hematology analyzer. Significantly higher serum CRP concentration, WBC and NEUT were found in the decompensated stage of heart failure (ISACHC III) compared with healthy dogs and with patients in ISACHC group II and ISACHC group I. Serum CRP concentration significantly positively correlated with WBC (r = 0.65, P < 0.001) and NEUT (r = 0.58, P = 0.002) in the ISACHC III group, while no significant correlations were found in the ISACHC I and II groups. A significant negative correlation between serum CRP concentration and the left ventricular ejection fraction (r = - 0.49, P = 0.046) and a significant positive correlation between CRP and the E wave velocity of the mitral valve inflow (r = 0.52, P = 0.046) were found in the ISACHC III group. The CRP concentration, WBC and NEUT were significantly increased in advanced-stage heart failure patients in comparison with compensated patients and healthy dogs, which indicate the presence of systemic inflammation. However, normal CRP concentration and normal WBC and NEUT can also be present in heart failure.

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Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 45 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 13 29%
Student > Postgraduate 9 20%
Other 3 7%
Student > Master 3 7%
Professor 3 7%
Other 7 16%
Unknown 7 16%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 18 40%
Medicine and Dentistry 8 18%
Agricultural and Biological Sciences 3 7%
Business, Management and Accounting 2 4%
Biochemistry, Genetics and Molecular Biology 2 4%
Other 4 9%
Unknown 8 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 March 2018.
All research outputs
#11,309,287
of 12,713,955 outputs
Outputs from Acta Veterinaria Scandinavica
#391
of 482 outputs
Outputs of similar age
#237,293
of 273,302 outputs
Outputs of similar age from Acta Veterinaria Scandinavica
#1
of 1 outputs
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So far Altmetric has tracked 482 research outputs from this source. They receive a mean Attention Score of 2.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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