Title |
Early B-cell Factor gene association with multiple sclerosis in the Spanish population
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Published in |
BMC Neurology, October 2005
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DOI | 10.1186/1471-2377-5-19 |
Pubmed ID | |
Authors |
Alfonso Martínez, Ana Mas, Virginia de las Heras, Rafael Arroyo, Miguel Fernández-Arquero, Emilio G de la Concha, Elena Urcelay |
Abstract |
The etiology of multiple sclerosis (MS) is at present not fully elucidated, although it is considered to result from the interaction of environmental and genetic susceptibility factors. In this work we aimed at testing the Early B-cell Factor (EBF1) gene as a functional and positional candidate risk factor for this neurological disease. Axonal damage is a hallmark for multiple sclerosis clinical disability and EBF plays an evolutionarily conserved role in the expression of proteins essential for axonal pathfinding. Failure of B-cell differentiation was found in EBF-deficient mice and involvement of B-lymphocytes in MS has been suggested from their presence in cerebrospinal fluid and lesions of patients. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 4% |
Unknown | 26 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Unspecified | 4 | 15% |
Researcher | 4 | 15% |
Student > Bachelor | 3 | 11% |
Student > Doctoral Student | 2 | 7% |
Other | 2 | 7% |
Other | 7 | 26% |
Unknown | 5 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 6 | 22% |
Neuroscience | 5 | 19% |
Unspecified | 4 | 15% |
Agricultural and Biological Sciences | 2 | 7% |
Nursing and Health Professions | 1 | 4% |
Other | 4 | 15% |
Unknown | 5 | 19% |