Title |
Alternative initiation and splicing in dicer gene expression in human breast cells
|
---|---|
Published in |
Breast Cancer Research, May 2005
|
DOI | 10.1186/bcr1043 |
Pubmed ID | |
Authors |
Charletha V Irvin-Wilson, Gautam Chaudhuri |
Abstract |
Dicer is a ribonuclease that mediates RNA interference both at the transcriptional and the post-transcriptional levels. Human dicer gene expression is regulated in different tissues. Dicer is responsible for the synthesis of microRNAs and short temporal (st)RNAs that regulate the expression of many genes. Thus, understanding the control of the expression of the dicer gene is essential for the appreciation of double-stranded (ds)RNA-mediated pathways of gene expression. Human dicer mRNA has many upstream open reading frames (uORFs) at the 5'-leader sequences (the nucleotide sequence between the 5'-end and the start codon of the major ORF), and we studied whether these elements at the 5'-leader sequences regulate the expression of the dicer gene. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 3% |
Brazil | 1 | 3% |
Unknown | 38 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 30% |
Student > Ph. D. Student | 8 | 20% |
Student > Bachelor | 5 | 13% |
Student > Master | 5 | 13% |
Professor | 2 | 5% |
Other | 4 | 10% |
Unknown | 4 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 23 | 57% |
Biochemistry, Genetics and Molecular Biology | 8 | 20% |
Medicine and Dentistry | 2 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Unknown | 6 | 15% |