Title |
A novel cardiovirus in wild rats
|
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Published in |
Virology Journal, March 2018
|
DOI | 10.1186/s12985-018-0968-9 |
Pubmed ID | |
Authors |
Yan Wang, Jing Zhao, Min Zheng, Zhijian Liu, Wang Li, Xingli Fu, Yuan Lin, Jiaqi Yuan, Jieji Zhao, Quan Shen, Xiaochun Wang, Hua Wang, Shixing Yang |
Abstract |
Cardioviruses cause severe illnesses in rodents and humans. In recent years, novel cardioviruses have been frequently found, which promoted further studies of the genetic diversity of cardioviruses. Using viral metagenomics, we genetically characterized a novel cardiovirus (named SX1) from wild rat feces. The genomic structure of SX1 shared similar features with those of the Theiler's murine encephalomyelitis viruses, including a leader protein, four structural proteins and seven non-structural proteins. Phylogenetic analysis based on both structural proteins and non-structural proteins coding regions showed that SX1 was formed into a separate branch, being located between the branches of Theiler's murine encephalomyelitis viruses and Thera viruses. Variable resides presented in the Ser/Thr rich domain of L protein, VP1 loops, and VP2 puffs distinguished SX1 from Theiler's murine encephalomyelitis viruses, suggesting the different antigenicity and pathogenicity of SX1. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 4 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 12 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Unspecified | 1 | 8% |
Other | 1 | 8% |
Lecturer | 1 | 8% |
Student > Doctoral Student | 1 | 8% |
Student > Bachelor | 1 | 8% |
Other | 3 | 25% |
Unknown | 4 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 3 | 25% |
Veterinary Science and Veterinary Medicine | 2 | 17% |
Unspecified | 1 | 8% |
Agricultural and Biological Sciences | 1 | 8% |
Unknown | 5 | 42% |