Title |
Characterization of the mouse Dazap1 gene encoding an RNA-binding protein that interacts with infertility factors DAZ and DAZL
|
---|---|
Published in |
BMC Genomics, September 2001
|
DOI | 10.1186/1471-2164-2-6 |
Pubmed ID | |
Authors |
Tiane Dai, Yanira Vera, Eduardo C Salido, Pauline H Yen |
Abstract |
DAZAP1 (DAZ Associated Protein 1) was originally identified by a yeast two-hybrid system through its interaction with a putative male infertility factor, DAZ (Deleted in Azoospermia). In vitro, DAZAP1 interacts with both the Y chromosome-encoded DAZ and an autosome-encoded DAZ-like protein, DAZL. DAZAP1 contains two RNA-binding domains (RBDs) and a proline-rich C-terminal portion, and is expressed most abundantly in the testis. To understand the biological function of DAZAP1 and the significance of its interaction with DAZ and DAZL, we isolated and characterized the mouse Dazap1 gene, and studied its expression and the subcellular localization of its protein product. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 6% |
Unknown | 15 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 38% |
Student > Bachelor | 2 | 13% |
Student > Doctoral Student | 1 | 6% |
Lecturer > Senior Lecturer | 1 | 6% |
Lecturer | 1 | 6% |
Other | 1 | 6% |
Unknown | 4 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 4 | 25% |
Biochemistry, Genetics and Molecular Biology | 3 | 19% |
Medicine and Dentistry | 2 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
Immunology and Microbiology | 1 | 6% |
Other | 3 | 19% |
Unknown | 2 | 13% |