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HIV-1 Tat protein enhances Microtubule polymerization

Overview of attention for article published in Retrovirology, February 2005
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Title
HIV-1 Tat protein enhances Microtubule polymerization
Published in
Retrovirology, February 2005
DOI 10.1186/1742-4690-2-5
Pubmed ID
Authors

Jean de Mareuil, Manon Carre, Pascale Barbier, Grant R Campbell, Sophie Lancelot, Sandrine Opi, Didier Esquieu, Jennifer D Watkins, Charles Prevot, Diane Braguer, Vincent Peyrot, Erwann P Loret

Abstract

HIV infection and progression to AIDS is characterized by the depletion of T cells, which could be due, in part, to apoptosis mediated by the extra-cellular HIV-encoded Tat protein as a consequence of Tat binding to tubulin. Microtubules are tubulin polymers that are essential for cell structure and division. Molecules that target microtubules induce apoptosis and are potent anti-cancer drugs. We studied the effect on tubulin polymerization of three Tat variants: Tat HxB2 and Tat Eli from patients who are rapid progressors (RP) and Tat Oyi from highly exposed but persistently seronegative (HEPS) patients. We compared the effect on tubulin polymerization of these Tat variants and peptides corresponding to different parts of the Tat sequence, with paclitaxel, an anti-cancer drug that targets microtubules.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 4%
South Africa 1 4%
Unknown 26 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 36%
Student > Master 5 18%
Student > Doctoral Student 3 11%
Student > Ph. D. Student 2 7%
Other 2 7%
Other 4 14%
Unknown 2 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 32%
Biochemistry, Genetics and Molecular Biology 5 18%
Immunology and Microbiology 5 18%
Chemistry 3 11%
Medicine and Dentistry 2 7%
Other 2 7%
Unknown 2 7%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 July 2019.
All research outputs
#8,534,528
of 25,371,288 outputs
Outputs from Retrovirology
#455
of 1,274 outputs
Outputs of similar age
#40,966
of 158,202 outputs
Outputs of similar age from Retrovirology
#4
of 7 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,274 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 158,202 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.