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Predictive multi-imaging biomarkers relevant for visual acuity in idiopathic macular telangiectasis type 1

Overview of attention for article published in BMC Ophthalmology, March 2018
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Title
Predictive multi-imaging biomarkers relevant for visual acuity in idiopathic macular telangiectasis type 1
Published in
BMC Ophthalmology, March 2018
DOI 10.1186/s12886-018-0737-y
Pubmed ID
Authors

Jingli Guo, WenYi Tang, Xiaofeng Ye, Haixiang Wu, Gezhi Xu, Wei Liu, Yongjin Zhang

Abstract

To evaluate the structural changes associated with visual acuity (VA) in patients with idiopathic macular telangiectasia (MT) type 1 using multimodal imaging modalities. A retrospective study of 14 patients with MT type 1 and of 10 eyes from 10 healthy individuals as age-matched controls was conducted. The medical records of patients who had undergone colour fundus photography, spectral domain optical coherence tomography (OCT), fluorescein angiography and OCT angiography were reviewed. Central macular thickness (CMT), the areas of macular oedema and ellipsoid zone (EZ) disruption, EZ length, disorganization of the retinal inner layers (DRIL) and external limiting membrane (ELM) disruption, as measured by spectral domain OCT; and vascular density and the foveal avascular zones (FAZ) of the superficial capillary plexus (SCP) and deep capillary plexus (DCP), as measured by OCT angiography, were assessed in MT type 1 eyes and correlated with VA. The mean baseline best-corrected VA of MT type 1 eyes was 0.45 ± 0.28. The mean CMT was 385.19 ± 75.21 μm in MT type 1 eyes and 252.43 ± 15.77 μm in contralateral eyes (Z = - 4.113, p < 0.001). The mean vessel density of the DCP was lower in MT type 1 eyes (47.25 ± 4.69%) than in contralateral eyes (53.93 ± 2.94%) and normal eyes (59.37 ± 2.50%) (Z = - 3.492, - 4.099; p < 0.001, < 0.001). The baseline logMAR VA was correlated with CMT (r = 0.682, p = 0.007), SCP density (r = - 0.652, p = 0.012), DCP density (r = - 0.700, p = 0.005), total area of EZ disruption (r = 0.649, p = 0.012); and total lengths of EZ (r = 0.681, p = 0.007), ELM (r = 0.699, p = 0.005) and DRIL (r = 0.707, p = 0.005) disruption in the 1-mm-diameter foveal region in MT type 1 eyes. Decreased DCP density and the presence of DRIL may be predictive biomarkers of VA in MT type 1. CMT, SCP density, total area of EZ disruption, and lengths of EZ and ELM disruption within the 1-mm-diameter central region were strongly associated with VA.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Other 3 13%
Student > Master 3 13%
Student > Bachelor 2 9%
Researcher 2 9%
Student > Ph. D. Student 2 9%
Other 1 4%
Unknown 10 43%
Readers by discipline Count As %
Medicine and Dentistry 8 35%
Nursing and Health Professions 3 13%
Neuroscience 2 9%
Unknown 10 43%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 March 2018.
All research outputs
#20,472,403
of 23,031,582 outputs
Outputs from BMC Ophthalmology
#2,150
of 2,409 outputs
Outputs of similar age
#293,438
of 332,024 outputs
Outputs of similar age from BMC Ophthalmology
#29
of 36 outputs
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