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Milk protein-based formulas containing different oils affect fatty acids balance in term infants: A randomized blinded crossover clinical trial

Overview of attention for article published in Lipids in Health and Disease, April 2017
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Title
Milk protein-based formulas containing different oils affect fatty acids balance in term infants: A randomized blinded crossover clinical trial
Published in
Lipids in Health and Disease, April 2017
DOI 10.1186/s12944-017-0457-y
Pubmed ID
Authors

Carolina Oliveira de Souza, Maria Efigênia Q. Leite, John Lasekan, Geraldine Baggs, Lorena Silva Pinho, Janice Izabel Druzian, Tereza Cristina M. Ribeiro, Ângela P. Mattos, José A. Menezes-Filho, Hugo Costa-Ribeiro

Abstract

Palm olein is used in infant formula fat blends in order to match the fatty acid profile of human milk. While the effects on fatty acid balance have been evaluated, the use of palm olein in combination with palm kernel oil and supplementation with docosahexaenoic acid (DHA) and arachidonic acid (ARA) has not been similarly assessed in infants. This study evaluated the effects of infant formulas containing different fat compositions on the balance of fat, fatty acids, and calcium. In this randomized, crossover, double-blinded study, 33 healthy term infants (68-159 ± 3 days of age at enrollment) were fed two formulas for 14 days in a tolerance period, followed by a 4-day metabolic balance period in 17 of the male subjects. The study compared two commercially available milk-based powdered formulas in Brazil; the PALM formula contained palm olein (44%), kernel palm oil (21.7%), and canola oil (18.5%) as the predominant fats, whereas the NoPALM formula contained other fat sources. Fat absorption (%) was greater for NoPALM versus PALM-fed infants (96.55 and 95.50%, respectively; p = 0.023). The absorption percentage of palmitic acid (C16:0) did not differ significantly between formulas (p > 0.05), but this acid was excreted at significantly higher concentrations in the PALM (29.42 mg/kg/day) than in the NoPALM (12.28 mg/kg/day) formula groups. DHA and ARA absorption percentages were also higher in NoPALM-fed infants. Calcium absorption was higher in NoPALM-fed infants (58.00%) compared to those fed PALM (40.90%), but the difference was not significant (p = 0.104) when calcium intake was used as a covariate. However, calcium retention was higher in NoPALM-fed infants compared to that in PALM-fed infants with or without calcium intake as a covariate. Adverse events did not differ between groups (p > 0.05). The absorption of essential fatty acids was similar for both formulas; however, long-chain polyunsaturated fatty acids (DHA and ARA) were better absorbed from the NoPALM formula. Fat absorption and calcium retention were lower in term infants fed the PALM-based formula. Clinicaltrial.gov # NCT00941564 .

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 113 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 113 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 18 16%
Researcher 14 12%
Student > Master 13 12%
Student > Ph. D. Student 6 5%
Professor > Associate Professor 6 5%
Other 16 14%
Unknown 40 35%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 15%
Medicine and Dentistry 14 12%
Nursing and Health Professions 13 12%
Biochemistry, Genetics and Molecular Biology 6 5%
Engineering 5 4%
Other 14 12%
Unknown 44 39%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 March 2018.
All research outputs
#20,472,403
of 23,031,582 outputs
Outputs from Lipids in Health and Disease
#1,208
of 1,459 outputs
Outputs of similar age
#269,272
of 309,064 outputs
Outputs of similar age from Lipids in Health and Disease
#22
of 25 outputs
Altmetric has tracked 23,031,582 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,459 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.