Title |
A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin
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Published in |
BMC Molecular and Cell Biology, April 2005
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DOI | 10.1186/1471-2121-6-23 |
Pubmed ID | |
Authors |
Hongzhi Xu, Michael D Hebert |
Abstract |
Cajal bodies (CBs) are nuclear suborganelles that play a role in the biogenesis of small nuclear ribonucleoproteins (snRNPs), which are crucial for pre-mRNA splicing. Upon nuclear reentry, Sm-class snRNPs localize first to the CB, where the snRNA moiety of the snRNP is modified. It is not clear how snRNPs target to the CB and are released from this structure after their modification. Coilin, the CB marker protein, may participate in snRNP biogenesis given that it can interact with snRNPs and SMN. SMN is crucial for snRNP assembly and is the protein mutated in the neurodegenerative disease Spinal Muscular Atrophy. Coilin knockout mice display significant viability problems and altered CB formation. Thus characterization of the CB and its associated proteins will give insight into snRNP biogenesis and clarify the dynamic organization of the nucleus. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | 7% |
Canada | 1 | 7% |
Unknown | 12 | 86% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 6 | 43% |
Student > Ph. D. Student | 3 | 21% |
Professor | 1 | 7% |
Student > Doctoral Student | 1 | 7% |
Unknown | 3 | 21% |
Readers by discipline | Count | As % |
---|---|---|
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Medicine and Dentistry | 2 | 14% |
Neuroscience | 2 | 14% |
Biochemistry, Genetics and Molecular Biology | 1 | 7% |
Unknown | 4 | 29% |