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A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin

Overview of attention for article published in BMC Molecular and Cell Biology, April 2005
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Title
A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin
Published in
BMC Molecular and Cell Biology, April 2005
DOI 10.1186/1471-2121-6-23
Pubmed ID
Authors

Hongzhi Xu, Michael D Hebert

Abstract

Cajal bodies (CBs) are nuclear suborganelles that play a role in the biogenesis of small nuclear ribonucleoproteins (snRNPs), which are crucial for pre-mRNA splicing. Upon nuclear reentry, Sm-class snRNPs localize first to the CB, where the snRNA moiety of the snRNP is modified. It is not clear how snRNPs target to the CB and are released from this structure after their modification. Coilin, the CB marker protein, may participate in snRNP biogenesis given that it can interact with snRNPs and SMN. SMN is crucial for snRNP assembly and is the protein mutated in the neurodegenerative disease Spinal Muscular Atrophy. Coilin knockout mice display significant viability problems and altered CB formation. Thus characterization of the CB and its associated proteins will give insight into snRNP biogenesis and clarify the dynamic organization of the nucleus.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 7%
Canada 1 7%
Unknown 12 86%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 43%
Student > Ph. D. Student 3 21%
Professor 1 7%
Student > Doctoral Student 1 7%
Unknown 3 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 36%
Medicine and Dentistry 2 14%
Neuroscience 2 14%
Biochemistry, Genetics and Molecular Biology 1 7%
Unknown 4 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#8,534,528
of 25,371,288 outputs
Outputs from BMC Molecular and Cell Biology
#334
of 1,233 outputs
Outputs of similar age
#24,370
of 69,674 outputs
Outputs of similar age from BMC Molecular and Cell Biology
#7
of 13 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,233 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 69,674 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.