Title |
Comparative genome analysis of cortactin and HS1: the significance of the F-actin binding repeat domain
|
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Published in |
BMC Genomics, February 2005
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DOI | 10.1186/1471-2164-6-15 |
Pubmed ID | |
Authors |
Agnes GSH van Rossum, Ellen Schuuring-Scholtes, Vera van Buuren-van Seggelen, Philip M Kluin, Ed Schuuring |
Abstract |
In human carcinomas, overexpression of cortactin correlates with poor prognosis. Cortactin is an F-actin-binding protein involved in cytoskeletal rearrangements and cell migration by promoting actin-related protein (Arp)2/3 mediated actin polymerization. It shares a high amino acid sequence and structural similarity to hematopoietic lineage cell-specific protein 1 (HS1) although their functions differ considerable. In this manuscript we describe the genomic organization of these two genes in a variety of species by a combination of cloning and database searches. Based on our analysis, we predict the genesis of the actin-binding repeat domain during evolution. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 43 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 15 | 35% |
Student > Master | 9 | 21% |
Researcher | 5 | 12% |
Student > Bachelor | 4 | 9% |
Student > Doctoral Student | 3 | 7% |
Other | 5 | 12% |
Unknown | 2 | 5% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 18 | 42% |
Biochemistry, Genetics and Molecular Biology | 9 | 21% |
Medicine and Dentistry | 5 | 12% |
Immunology and Microbiology | 3 | 7% |
Social Sciences | 1 | 2% |
Other | 3 | 7% |
Unknown | 4 | 9% |