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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A vicious circle between insulin resistance and inflammation in nonalcoholic fatty liver disease
|
|---|---|
| Published in |
Lipids in Health and Disease, October 2017
|
| DOI | 10.1186/s12944-017-0572-9 |
| Pubmed ID | |
| Authors |
Zhonge Chen, Rong Yu, Ying Xiong, Fangteng Du, Shuishan Zhu |
| Abstract |
Nonalcoholic fatty liver disease (NAFLD) comprises a spectrum of diseases, including simple steatosis, nonalcoholic steatohepatitis (NASH), liver cirrhosis and hepatocellular carcinoma. Lipotoxicity, insulin resistance (IR) and inflammation are involved in the disease process. Lipotoxicity promotes inflammation and IR, which in turn, increase adipocyte lipolysis and exacerbates lipotoxicity. Furthermore, IR and inflammation form a vicious circle, with each condition promoting the other and accelerating the development of NAFLD in the presence of lipotoxicity. As an integrator of inflammatory pathway networks, nuclear factor-kappa B (NF-κB) regulates expression of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6), and anti-inflammatory cytokines, such as adiponectin in NAFLD. In this review, the relationships between lipotoxicity, IR and inflammation in NAFLD are discussed, with particular emphasis on the inflammatory pathways. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 227 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 227 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 33 | 15% |
| Student > Master | 32 | 14% |
| Student > Ph. D. Student | 27 | 12% |
| Student > Doctoral Student | 20 | 9% |
| Researcher | 13 | 6% |
| Other | 30 | 13% |
| Unknown | 72 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 50 | 22% |
| Biochemistry, Genetics and Molecular Biology | 39 | 17% |
| Agricultural and Biological Sciences | 16 | 7% |
| Nursing and Health Professions | 11 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 11 | 5% |
| Other | 17 | 7% |
| Unknown | 83 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 March 2018.
All research outputs
#6,540,389
of 24,217,893 outputs
Outputs from Lipids in Health and Disease
#393
of 1,533 outputs
Outputs of similar age
#100,723
of 329,531 outputs
Outputs of similar age from Lipids in Health and Disease
#6
of 32 outputs
Altmetric has tracked 24,217,893 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 1,533 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,531 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.