Title |
hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands
|
---|---|
Published in |
Molecular Cancer, June 2007
|
DOI | 10.1186/1476-4598-6-37 |
Pubmed ID | |
Authors |
Mohamed M Desouki, Joseph Geradts, Beatrice Milon, Renty B Franklin, Leslie C Costello |
Abstract |
The normal human prostate glandular epithelium has the unique function of accumulating high levels of zinc. In prostate cancer this capability is lost as an early event in the development of the malignant cells. The mechanism and factors responsible for the ability of the normal epithelial cells to accumulate zinc and the loss of this capability in the malignant cells need to be identified. We previously reported that Zip1 is an important zinc uptake transporter in prostate cells and is down regulated in the malignant cells in situ along with the depletion of zinc levels. In this report we investigated the expression of two other Zip family zinc transporters, Zip2 and Zip3 in malignant versus nonmalignant (normal and BPH) glands. Zip2 and Zip3 relative protein levels were determined by immunohistochemistry analysis of human prostate tissue sections. |
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