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Identification of immunologic and clinical characteristics that predict inflammatory response to C. Novyi-NT bacteriolytic immunotherapy

Overview of attention for article published in BMC Veterinary Research, April 2018
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Mentioned by

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4 tweeters

Citations

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1 Dimensions

Readers on

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11 Mendeley
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Title
Identification of immunologic and clinical characteristics that predict inflammatory response to C. Novyi-NT bacteriolytic immunotherapy
Published in
BMC Veterinary Research, April 2018
DOI 10.1186/s12917-018-1424-1
Pubmed ID
Authors

Amy E. DeClue, Sandra M. Axiak-Bechtel, Yan Zhang, Saurabh Saha, Linping Zhang, David D. Tung, Jeffrey N. Bryan

Abstract

Clostridium novyi-NT (CNV-NT), has shown promise as a bacterolytic therapy for solid tumors in mouse models and in dogs with naturally developing neoplasia. Factors that impact the immunologic response to therapy are largely unknown. The goal of this pilot study was to determine if plasma immune biomarkers, immune cell function, peripheral blood cytological composition and tumor characteristics including evaluation of a PET imaging surrogate of tumor tissue hypoxia could predict which dogs with naturally developing naïve neoplasia would develop an inflammatory response to CNV-NT. Dogs that developed an inflammatory response to CNV-NT had a higher heart rate, larger gross tumor volume, greater tumor [64Cu]ATSM SUVMax, increased constitutive leukocyte IL-10 production, more robust NK cell-like function and greater peripheral blood lymphocyte counts compared to dogs that did not develop an inflammatory response to CNV-NT. Of these, unstimulated leukocyte IL-10 production, heart rate, and gross tumor volume appeared to be the best predictors of which dogs will develop an inflammatory response to CNV-NT. Development of inflammation in response to CNV-NT is best predicted by pretreatment unstimulated leukocyte IL-10 production, heart rate, and gross tumor volume.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 27%
Professor 1 9%
Other 1 9%
Student > Ph. D. Student 1 9%
Student > Master 1 9%
Other 1 9%
Unknown 3 27%
Readers by discipline Count As %
Medicine and Dentistry 3 27%
Veterinary Science and Veterinary Medicine 2 18%
Psychology 1 9%
Agricultural and Biological Sciences 1 9%
Materials Science 1 9%
Other 0 0%
Unknown 3 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 April 2018.
All research outputs
#8,458,566
of 13,488,230 outputs
Outputs from BMC Veterinary Research
#910
of 1,985 outputs
Outputs of similar age
#161,824
of 270,659 outputs
Outputs of similar age from BMC Veterinary Research
#2
of 2 outputs
Altmetric has tracked 13,488,230 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,985 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,659 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.