Title |
High levels of sulphadoxine-pyrimethamine resistance Pfdhfr-Pfdhps quintuple mutations: a cross sectional survey of six regions in Tanzania
|
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Published in |
Malaria Journal, April 2014
|
DOI | 10.1186/1475-2875-13-152 |
Pubmed ID | |
Authors |
Sungwa I Matondo, Godfrey S Temba, Adelaida A Kavishe, Julius S Kauki, Akili Kalinga, Marco van Zwetselaar, Hugh Reyburn, Reginald A Kavishe |
Abstract |
In 2006, the first-line anti-malarial drug treatment in Tanzania was changed from sulphadoxine-pyrimethamine (SP) to artemether-lumefantrine (ALu), an artemisinin-based combination (ACT), since when the use of SP has been restricted for intermittent preventive treatment in pregnancy (IPTp). A number of Plasmodium falciparum mutations are known to be associated with resistance to SP, but it is not known if the prevalence of these mutations is increasing or decreasing under the conditions of reduced levels of SP use. This study reports on the current SP resistant quintuple Pfdhfr-Pfdhps mutations in six regions of Tanzania. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 1% |
India | 1 | <1% |
Senegal | 1 | <1% |
Unknown | 169 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 40 | 23% |
Student > Ph. D. Student | 31 | 18% |
Researcher | 20 | 12% |
Student > Bachelor | 18 | 10% |
Student > Doctoral Student | 11 | 6% |
Other | 20 | 12% |
Unknown | 33 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 49 | 28% |
Agricultural and Biological Sciences | 23 | 13% |
Biochemistry, Genetics and Molecular Biology | 21 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 11 | 6% |
Nursing and Health Professions | 10 | 6% |
Other | 26 | 15% |
Unknown | 33 | 19% |