Title |
Multilocus sequence typing of Cronobacter sakazakii and Cronobacter malonaticus reveals stable clonal structures with clinical significance which do not correlate with biotypes
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Published in |
BMC Microbiology, October 2009
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DOI | 10.1186/1471-2180-9-223 |
Pubmed ID | |
Authors |
Adam Baldwin, Michael Loughlin, Juncal Caubilla-Barron, Eva Kucerova, Georgina Manning, Christopher Dowson, Stephen Forsythe |
Abstract |
The Cronobacter genus (Enterobacter sakazakii) has come to prominence due to its association with infant infections, and the ingestion of contaminated reconstituted infant formula. C. sakazakii and C. malonaticus are closely related, and are defined according their biotype. Due to the ubiquitous nature of the organism, and the high severity of infection for the immunocompromised, a multilocus sequence typing (MLST) scheme has been developed for the fast and reliable identification and discrimination of C. sakazakii and C. malonaticus strains. It was applied to 60 strains of C. sakazakii and 16 strains of C. malonaticus, including the index strains used to define the biotypes. The strains were from clinical and non-clinical sources between 1951 and 2008 in USA, Canada, Europe, New Zealand and the Far East. |
Mendeley readers
Geographical breakdown
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United Kingdom | 2 | 3% |
France | 1 | 2% |
South Africa | 1 | 2% |
Unknown | 60 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 14 | 22% |
Student > Bachelor | 12 | 19% |
Student > Master | 7 | 11% |
Student > Postgraduate | 6 | 9% |
Professor | 3 | 5% |
Other | 12 | 19% |
Unknown | 10 | 16% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 9 | 14% |
Veterinary Science and Veterinary Medicine | 3 | 5% |
Immunology and Microbiology | 3 | 5% |
Chemistry | 3 | 5% |
Other | 4 | 6% |
Unknown | 12 | 19% |